Anti-angiogenic therapies for malignant pleural mesothelioma

Giovanni Luca Ceresoli, Paolo Andrea Zucali

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Malignant pleural mesothelioma (MPM) is a disease with a dismal prognosis. Currently available treatments have modest results. Therefore, new agents and new treatment strategies are eagerly awaited by patients and clinicians. Preclinical and clinical studies have shown that angiogenesis plays a very important role in MPM. Therefore, a great hope has been placed in the use of anti-angiogenic agents in this disease. Areas covered: Studies regarding anti-angiogenic treatments in MPM with bevacizumab, tyrosine-kinase inhibitors (TKIs) and other agents were critically analyzed, with an overview of ongoing trials and future perspectives, including research on biomarkers. Expert opinion: The clinical use of angiogenesis inhibitors in MPM patients has resulted more challenging than anticipated. The intrinsic complexity of neo-angiogenesis, and its redundant regulatory mechanisms, suggests that multiple and different biomarkers are needed to predict efficacy of anti-angiogenic agents and to monitor their biological and therapeutic effects. The growing understanding of the molecular alterations and key pathways that underlie the resistance to VEGF inhibitors will allow to design studies of the combination of agents targeting these pathways with anti-VEGF therapies. Only a tight integration of preclinical and clinical studies will allow to achieve a real progress in MPM patients with this therapeutic strategy.

Original languageEnglish
Pages (from-to)833-844
Number of pages12
JournalExpert Opinion on Investigational Drugs
Volume21
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Angiogenesis
  • Biomarkers
  • Malignant pleural mesothelioma
  • Therapy

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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