Anti-beta 2 glycoprotein I antibodies in centenarians

P. L. Meroni, D. Mari, D. Monti, R. Coppola, M. Capri, S. Salvioli, A. Tincani, R. Gerli, C. Franceschi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Non-organ-specific autoantibodies are present in centenarians without evidence of autoimmune diseases but conflicting or no data on anti-phospholipid and anti-phospholipid binding proteins were reported. To investigate the presence and antigen specificity of anti-phospholipid and anti-phospholipid binding proteins in centenarians. Seventy-seven centenarians, 70 adult controls, 65 unselected elderly subjects, and 38 old SENIEUR volunteers were investigated. Anti-cardiolipin, anti-human β2glycoprotein I, and lupus anticoagulant were detected. Antigen specificity was assayed against plates coated with anionic, neutral and cationic phospholipids and β2glycoprotein I-dependence was also evaluated. 54.3% of the centenarians were positive for IgG and 8.6% for IgM anti-β2glycoprotein I antibodies, while only 20.7% centenarians were positive for anti-cardiolipin IgG and 2.59% for IgM; none resulted positive for lupus anticoagulant. Anti-cardiolipin positive sera cross-reacted with negatively charged phospholipids and displayed decreased binding to serum-free cardiolipin-coated plates that was restored by human β2glycoprotein I or fetal calf serum. Centenarians display high reactivity against human β2glycoprotein I but low binding to the bovine molecule in the anti-cardiolipin assay. In spite of the presence of antibodies comparable to those found in patients with the anti-phospholipid syndrome, no vascular events were reported suggesting the presence of unknown protective factors and/or the lack of triggering factors.

Original languageEnglish
Pages (from-to)1459-1465
Number of pages7
JournalExperimental Gerontology
Volume39
Issue number10
DOIs
Publication statusPublished - Oct 2004

Fingerprint

beta 2-Glycoprotein I
Cardiolipins
Phospholipids
Antibodies
Lupus Coagulation Inhibitor
Carrier Proteins
Serum
Immunoglobulin G
Antigens
Antiphospholipid Syndrome
Autoantibodies
Autoimmune Diseases
Immunoglobulin M
Blood Vessels
Volunteers
Assays
Molecules

Keywords

  • β2Glycoprotein I
  • Ageing
  • Anti-phospholipid antibodies
  • Centenarians
  • Thrombosis

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

Cite this

Anti-beta 2 glycoprotein I antibodies in centenarians. / Meroni, P. L.; Mari, D.; Monti, D.; Coppola, R.; Capri, M.; Salvioli, S.; Tincani, A.; Gerli, R.; Franceschi, C.

In: Experimental Gerontology, Vol. 39, No. 10, 10.2004, p. 1459-1465.

Research output: Contribution to journalArticle

Meroni, PL, Mari, D, Monti, D, Coppola, R, Capri, M, Salvioli, S, Tincani, A, Gerli, R & Franceschi, C 2004, 'Anti-beta 2 glycoprotein I antibodies in centenarians', Experimental Gerontology, vol. 39, no. 10, pp. 1459-1465. https://doi.org/10.1016/j.exger.2004.08.003
Meroni PL, Mari D, Monti D, Coppola R, Capri M, Salvioli S et al. Anti-beta 2 glycoprotein I antibodies in centenarians. Experimental Gerontology. 2004 Oct;39(10):1459-1465. https://doi.org/10.1016/j.exger.2004.08.003
Meroni, P. L. ; Mari, D. ; Monti, D. ; Coppola, R. ; Capri, M. ; Salvioli, S. ; Tincani, A. ; Gerli, R. ; Franceschi, C. / Anti-beta 2 glycoprotein I antibodies in centenarians. In: Experimental Gerontology. 2004 ; Vol. 39, No. 10. pp. 1459-1465.
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