Anti-beta 2 glycoprotein I antibodies in centenarians

P. L. Meroni, D. Mari, D. Monti, R. Coppola, M. Capri, S. Salvioli, A. Tincani, R. Gerli, C. Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

Non-organ-specific autoantibodies are present in centenarians without evidence of autoimmune diseases but conflicting or no data on anti-phospholipid and anti-phospholipid binding proteins were reported. To investigate the presence and antigen specificity of anti-phospholipid and anti-phospholipid binding proteins in centenarians. Seventy-seven centenarians, 70 adult controls, 65 unselected elderly subjects, and 38 old SENIEUR volunteers were investigated. Anti-cardiolipin, anti-human β2glycoprotein I, and lupus anticoagulant were detected. Antigen specificity was assayed against plates coated with anionic, neutral and cationic phospholipids and β2glycoprotein I-dependence was also evaluated. 54.3% of the centenarians were positive for IgG and 8.6% for IgM anti-β2glycoprotein I antibodies, while only 20.7% centenarians were positive for anti-cardiolipin IgG and 2.59% for IgM; none resulted positive for lupus anticoagulant. Anti-cardiolipin positive sera cross-reacted with negatively charged phospholipids and displayed decreased binding to serum-free cardiolipin-coated plates that was restored by human β2glycoprotein I or fetal calf serum. Centenarians display high reactivity against human β2glycoprotein I but low binding to the bovine molecule in the anti-cardiolipin assay. In spite of the presence of antibodies comparable to those found in patients with the anti-phospholipid syndrome, no vascular events were reported suggesting the presence of unknown protective factors and/or the lack of triggering factors.

Original languageEnglish
Pages (from-to)1459-1465
Number of pages7
JournalExperimental Gerontology
Volume39
Issue number10
DOIs
Publication statusPublished - Oct 2004

Keywords

  • β2Glycoprotein I
  • Ageing
  • Anti-phospholipid antibodies
  • Centenarians
  • Thrombosis

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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