Anti-brain but not celiac disease antibodies in Landau-Kleffner Syndrome and related epilepsies

S. Boscolo, V. Baldas, G. Gobbi, L. Giordano, G. Cioni, T. Not, A. Ventura, E. Tongiorgi

Research output: Contribution to journalArticlepeer-review

Abstract

The Landau-Kleffner syndrome, the continuous spikes-waves during slow sleep syndrome and the benign epilepsy of childhood with rolandic spikes are rare childhood epilepsies with unknown etiology. Improvement in patients treated with immunoglobulin suggests an involvement of the immune system. We provide immunohistochemical evidence of autoantibodies against rat brain auditory cortex, brainstem and cerebellum, in children suffering with one or more of these syndromes. Only 1/14 patient was celiac.

Original languageEnglish
Pages (from-to)228-232
Number of pages5
JournalJournal of Neuroimmunology
Volume160
Issue number1-2
DOIs
Publication statusPublished - Mar 2005

Keywords

  • Anti-brain autoantibodies
  • Autoimmunity
  • Pediatric epilepsy

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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