Anti-brain but not celiac disease antibodies in Landau-Kleffner Syndrome and related epilepsies

S. Boscolo; V. Baldas; G. Gobbi; L. Giordano; G. Cioni; T. Not; A. Ventura; E. Tongiorgi

doi:10.1016/j.jneuroim.2004.10.031

Anti-brain but not celiac disease antibodies in Landau-Kleffner Syndrome and related epilepsies

S. Boscolo, V. Baldas, G. Gobbi, L. Giordano, G. Cioni, T. Not, A. Ventura, E. Tongiorgi

Research output: Contribution to journal › Article › peer-review

Abstract

The Landau-Kleffner syndrome, the continuous spikes-waves during slow sleep syndrome and the benign epilepsy of childhood with rolandic spikes are rare childhood epilepsies with unknown etiology. Improvement in patients treated with immunoglobulin suggests an involvement of the immune system. We provide immunohistochemical evidence of autoantibodies against rat brain auditory cortex, brainstem and cerebellum, in children suffering with one or more of these syndromes. Only 1/14 patient was celiac.

Original language	English
Pages (from-to)	228-232
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	160
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2004.10.031
Publication status	Published - Mar 2005

Keywords

Anti-brain autoantibodies
Autoimmunity
Pediatric epilepsy

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

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abstract = "The Landau-Kleffner syndrome, the continuous spikes-waves during slow sleep syndrome and the benign epilepsy of childhood with rolandic spikes are rare childhood epilepsies with unknown etiology. Improvement in patients treated with immunoglobulin suggests an involvement of the immune system. We provide immunohistochemical evidence of autoantibodies against rat brain auditory cortex, brainstem and cerebellum, in children suffering with one or more of these syndromes. Only 1/14 patient was celiac.",

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AU - Boscolo, S.

AU - Baldas, V.

AU - Gobbi, G.

AU - Giordano, L.

AU - Cioni, G.

AU - Not, T.

AU - Ventura, A.

AU - Tongiorgi, E.

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KW - Autoimmunity

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Anti-brain but not celiac disease antibodies in Landau-Kleffner Syndrome and related epilepsies

Abstract

Keywords

ASJC Scopus subject areas

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