Anti-C1q autoantibodies in lupus nephritis

Renato Alberto Sinico, Laura Rimoldi, Antonella Radice, Laura Bianchi, Beniamina Gallelli, Gabriella Moroni

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Anti-C1q antibodies are found in a variety of diseases, in addition to systemic lupus erythematosus (SLE), and in 3-5% of normal individuals. In particular, anti-C1q antibodies are detected at a high titer in 100% of patients with hypocomplementemic urticarial vasculitis and in 30-48% of SLE patients. Their titer correlates with active renal disease with a sensitivity of 44-100% and a specificity of 70-92%. An increase in anti-C1q antibody titer has been suggested to be able to predict renal flares in lupus nephritis so that monitoring anti-C1q might be valuable for the clinical management of SLE patients as a noninvasive biological marker. Recently our group studied 228 patients affected by lupus nephritis and found that the association of anti-C1q, C3, and C4, in a multivariate analysis, provided the best prediction of renal flares, particularly in patients with focal and diffuse proliferative lupus nephritis and in the absence of antiphospholipid antibodies.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Number of pages5
Publication statusPublished - Sep 2009

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)00778923
ISSN (Electronic)17496632


  • Anti-C1q antibodies
  • Anti-DNA antibodies
  • C3
  • Lupus nephritis
  • Renal flare

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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