Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols

Claudia Bello; Giovanna Dal Bello; Michele Cea; Aimable Nahimana; Dominique Aubry; Anna Garuti; Giulia Motta; Eva Moran; Floriana Fruscione; Paolo Pronzato; Francesco Grossi; Franco Patrone; Alberto Ballestrero; Marc Dupuis; Bernard Sordat; Kaspar Zimmermann; Jacqueline Loretan; Markus Wartmann; Michel A. Duchosal; Alessio Nencioni; Pierre Vogel

doi:10.1016/j.bmc.2011.07.053

Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols

Claudia Bello, Giovanna Dal Bello, Michele Cea, Aimable Nahimana, Dominique Aubry, Anna Garuti, Giulia Motta, Eva Moran, Floriana Fruscione, Paolo Pronzato, Francesco Grossi, Franco Patrone, Alberto Ballestrero, Marc Dupuis, Bernard Sordat, Kaspar Zimmermann, Jacqueline Loretan, Markus Wartmann, Michel A. Duchosal, Alessio NencioniPierre Vogel

Research output: Contribution to journal › Article › peer-review

Abstract

New derivatives of 1,4-dideoxy-1,4-imino-d-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-d-ribitol (13, IC ₅₀ ∼2 μM) and its C ₁₈-analogues (IC ₅₀ 50 ∼8 μM) growth of JURKAT cells.

Original language	English
Pages (from-to)	7720-7727
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry
Volume	19
Issue number	24
DOIs	https://doi.org/10.1016/j.bmc.2011.07.053
Publication status	Published - Dec 15 2011

Keywords

Breast cancer
Iminoalditols
JURKAT cells
Oleyl derivative

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Organic Chemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry
Biochemistry

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10.1016/j.bmc.2011.07.053

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Bello, C., Dal Bello, G., Cea, M., Nahimana, A., Aubry, D., Garuti, A., Motta, G., Moran, E., Fruscione, F., Pronzato, P., Grossi, F., Patrone, F., Ballestrero, A., Dupuis, M., Sordat, B., Zimmermann, K., Loretan, J., Wartmann, M., Duchosal, M. A., ... Vogel, P. (2011). Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols. Bioorganic and Medicinal Chemistry, 19(24), 7720-7727. https://doi.org/10.1016/j.bmc.2011.07.053

Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols. / Bello, Claudia; Dal Bello, Giovanna; Cea, Michele; Nahimana, Aimable; Aubry, Dominique; Garuti, Anna; Motta, Giulia; Moran, Eva; Fruscione, Floriana; Pronzato, Paolo ; Grossi, Francesco; Patrone, Franco; Ballestrero, Alberto; Dupuis, Marc; Sordat, Bernard; Zimmermann, Kaspar; Loretan, Jacqueline; Wartmann, Markus; Duchosal, Michel A.; Nencioni, Alessio; Vogel, Pierre.

In: Bioorganic and Medicinal Chemistry, Vol. 19, No. 24, 15.12.2011, p. 7720-7727.

Research output: Contribution to journal › Article › peer-review

Bello, C, Dal Bello, G, Cea, M, Nahimana, A, Aubry, D, Garuti, A, Motta, G, Moran, E, Fruscione, F, Pronzato, P , Grossi, F, Patrone, F, Ballestrero, A, Dupuis, M, Sordat, B, Zimmermann, K, Loretan, J, Wartmann, M, Duchosal, MA, Nencioni, A & Vogel, P 2011, 'Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols', Bioorganic and Medicinal Chemistry, vol. 19, no. 24, pp. 7720-7727. https://doi.org/10.1016/j.bmc.2011.07.053

Bello, Claudia ; Dal Bello, Giovanna ; Cea, Michele ; Nahimana, Aimable ; Aubry, Dominique ; Garuti, Anna ; Motta, Giulia ; Moran, Eva ; Fruscione, Floriana ; Pronzato, Paolo ; Grossi, Francesco ; Patrone, Franco ; Ballestrero, Alberto ; Dupuis, Marc ; Sordat, Bernard ; Zimmermann, Kaspar ; Loretan, Jacqueline ; Wartmann, Markus ; Duchosal, Michel A. ; Nencioni, Alessio ; Vogel, Pierre. / Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols. In: Bioorganic and Medicinal Chemistry. 2011 ; Vol. 19, No. 24. pp. 7720-7727.

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abstract = "New derivatives of 1,4-dideoxy-1,4-imino-d-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-d-ribitol (13, IC 50 ∼2 μM) and its C 18-analogues (IC 50 50 ∼8 μM) growth of JURKAT cells.",

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AU - Cea, Michele

AU - Nahimana, Aimable

AU - Aubry, Dominique

AU - Garuti, Anna

AU - Motta, Giulia

AU - Moran, Eva

AU - Fruscione, Floriana

AU - Pronzato, Paolo

AU - Grossi, Francesco

AU - Patrone, Franco

AU - Ballestrero, Alberto

AU - Dupuis, Marc

AU - Sordat, Bernard

AU - Zimmermann, Kaspar

AU - Loretan, Jacqueline

AU - Wartmann, Markus

AU - Duchosal, Michel A.

AU - Nencioni, Alessio

AU - Vogel, Pierre

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AB - New derivatives of 1,4-dideoxy-1,4-imino-d-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-d-ribitol (13, IC 50 ∼2 μM) and its C 18-analogues (IC 50 50 ∼8 μM) growth of JURKAT cells.

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KW - Iminoalditols

KW - JURKAT cells

KW - Oleyl derivative

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Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols

Abstract

Keywords

ASJC Scopus subject areas

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