Abstract
New derivatives of 1,4-dideoxy-1,4-imino-d-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-d-ribitol (13, IC 50 ∼2 μM) and its C 18-analogues (IC 50 50 ∼8 μM) growth of JURKAT cells.
Original language | English |
---|---|
Pages (from-to) | 7720-7727 |
Number of pages | 8 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 19 |
Issue number | 24 |
DOIs | |
Publication status | Published - Dec 15 2011 |
Keywords
- Breast cancer
- Iminoalditols
- JURKAT cells
- Oleyl derivative
ASJC Scopus subject areas
- Pharmaceutical Science
- Drug Discovery
- Organic Chemistry
- Molecular Medicine
- Molecular Biology
- Clinical Biochemistry
- Biochemistry