Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus

C. Pupilli, A. Antonelli, L. Iughetti, G. D'Annunzio, M. Cotellessa, M. Vanelli, H. Okamoto, R. Lorini, Ele Ferrannini

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To test for anti-CD38 autoimmunity in children with newly-diagnosed type 1 diabetes mellitus (DM1). Methods: Serum anti-CD38 autoantibodies were detected by Western blot in 270 children (130 girls, 140 boys, mean age 8 ± 4 years) with newly-diagnosed DM1. and 179 gender- and age-matched non-diabetic children. In 126 diabetic children, another blood sample was obtained 15 ± 4 months after the diagnosis. Results: Anti-CD38 autoantibody titers at least 3 SD above the mean value for the control group were found in 4.4% of children with DM1 vs 0.6% of controls (χ2 = 5.8, p

Original languageEnglish
Pages (from-to)1417-1423
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Volume18
Issue number12
Publication statusPublished - Dec 2005

Keywords

  • CD38 antibodies
  • Children
  • GAD antibodies
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

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