Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus

C. Pupilli, A. Antonelli, L. Iughetti, G. D'Annunzio, M. Cotellessa, M. Vanelli, H. Okamoto, R. Lorini, Ele Ferrannini

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aims: To test for anti-CD38 autoimmunity in children with newly-diagnosed type 1 diabetes mellitus (DM1). Methods: Serum anti-CD38 autoantibodies were detected by Western blot in 270 children (130 girls, 140 boys, mean age 8 ± 4 years) with newly-diagnosed DM1. and 179 gender- and age-matched non-diabetic children. In 126 diabetic children, another blood sample was obtained 15 ± 4 months after the diagnosis. Results: Anti-CD38 autoantibody titers at least 3 SD above the mean value for the control group were found in 4.4% of children with DM1 vs 0.6% of controls (χ2 = 5.8, p

Original languageEnglish
Pages (from-to)1417-1423
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Volume18
Issue number12
Publication statusPublished - Dec 2005

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Autoimmunity
Type 1 Diabetes Mellitus
Autoantibodies
Western Blotting
Control Groups
Serum

Keywords

  • CD38 antibodies
  • Children
  • GAD antibodies
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

Cite this

Pupilli, C., Antonelli, A., Iughetti, L., D'Annunzio, G., Cotellessa, M., Vanelli, M., ... Ferrannini, E. (2005). Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus. Journal of Pediatric Endocrinology and Metabolism, 18(12), 1417-1423.

Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus. / Pupilli, C.; Antonelli, A.; Iughetti, L.; D'Annunzio, G.; Cotellessa, M.; Vanelli, M.; Okamoto, H.; Lorini, R.; Ferrannini, Ele.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 18, No. 12, 12.2005, p. 1417-1423.

Research output: Contribution to journalArticle

Pupilli, C, Antonelli, A, Iughetti, L, D'Annunzio, G, Cotellessa, M, Vanelli, M, Okamoto, H, Lorini, R & Ferrannini, E 2005, 'Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus', Journal of Pediatric Endocrinology and Metabolism, vol. 18, no. 12, pp. 1417-1423.
Pupilli C, Antonelli A, Iughetti L, D'Annunzio G, Cotellessa M, Vanelli M et al. Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus. Journal of Pediatric Endocrinology and Metabolism. 2005 Dec;18(12):1417-1423.
Pupilli, C. ; Antonelli, A. ; Iughetti, L. ; D'Annunzio, G. ; Cotellessa, M. ; Vanelli, M. ; Okamoto, H. ; Lorini, R. ; Ferrannini, Ele. / Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus. In: Journal of Pediatric Endocrinology and Metabolism. 2005 ; Vol. 18, No. 12. pp. 1417-1423.
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