Anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus patients with articular involvement: A predictive marker for erosive disease?

M. Taraborelli, F. Inverardi, M. Fredi, A. Ceribelli, I. Cavazzana, A. Tincani, F. Franceschini

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A small number of systemic lupus erythematosus (SLE) patients develops an erosive disease. Some studies have suggested an association between anti-cyclic citrullinated (anti-CCP) antibodies and this pattern of arthritis, but their exact significance in SLE patients remains unclear. The aim of this study was to evaluate the prevalence of anti-CCP antibodies in SLE patients with different subsets of articular disease. Among 521 SLE patients followed in this center from 1976 to 2011, those with articular involvement (n=298) were selected to take part in the study. We searched for anti-CCP2 IgG antibodies in 198 patients using a commercial enzyme linked immunosorbent assay (Immunoscan RA, Eurodiagnostica). In 174 patients the results for rheumatoid factor (RF) by nephelometry were retrospectively collected. C reactive protein (CRP) was obtained from clinical records. Patients were classified into 3 groups: erosive, non-erosive deforming, non-erosive non-deforming arthritis. Results of the different tests were compared among the groups. P

Original languageEnglish
Pages (from-to)321-325
Number of pages5
JournalReumatismo
Volume64
Issue number5
Publication statusPublished - 2012

Fingerprint

Systemic Lupus Erythematosus
Joints
Antibodies
Arthritis
Anti-Idiotypic Antibodies
Nephelometry and Turbidimetry
Rheumatoid Factor
cyclic citrullinated peptide
C-Reactive Protein
Enzyme-Linked Immunosorbent Assay

Keywords

  • Anti-cyclic citrullinated peptide antibodies
  • Arthtritis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

Cite this

Anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus patients with articular involvement : A predictive marker for erosive disease? / Taraborelli, M.; Inverardi, F.; Fredi, M.; Ceribelli, A.; Cavazzana, I.; Tincani, A.; Franceschini, F.

In: Reumatismo, Vol. 64, No. 5, 2012, p. 321-325.

Research output: Contribution to journalArticle

Taraborelli, M, Inverardi, F, Fredi, M, Ceribelli, A, Cavazzana, I, Tincani, A & Franceschini, F 2012, 'Anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus patients with articular involvement: A predictive marker for erosive disease?', Reumatismo, vol. 64, no. 5, pp. 321-325.
Taraborelli, M. ; Inverardi, F. ; Fredi, M. ; Ceribelli, A. ; Cavazzana, I. ; Tincani, A. ; Franceschini, F. / Anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus patients with articular involvement : A predictive marker for erosive disease?. In: Reumatismo. 2012 ; Vol. 64, No. 5. pp. 321-325.
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