TY - JOUR
T1 - Anti-cyclic citrullinated peptide antibody titer predicts time to Rheumatoid Arthritis Onset In Patients With Undifferentiated Arthritis
T2 - Results from a 2-year prospective study
AU - Bizzaro, Nicola
AU - Bartoloni, Elena
AU - Morozzi, Gabriella
AU - Manganelli, Stefania
AU - Riccieri, Valeria
AU - Sabatini, Paola
AU - Filippini, Matteo
AU - Tampoia, Marilina
AU - Afeltra, Antonella
AU - Sebastiani, Giandomenico
AU - Alpini, Claudia
AU - Bini, Vittorio
AU - Bistoni, Onelia
AU - Alunno, Alessia
AU - Gerli, Roberto
PY - 2013/1/22
Y1 - 2013/1/22
N2 - Introduction: The diagnostic, predictive and prognostic role of anti-cyclic citrullinated peptide (CCP) antibodies in rheumatoid arthritis (RA) patients is widely accepted. Moreover, detection of these antibodies in subjects presenting with undifferentiated arthritis (UA) is associated with a significant risk to develop the disease. On the other hand, clinical and prognostic significance of evaluating anti-CCP levels in subjects with inflammatory arthritis at disease onset has not been fully clarified. The goal of this prospective study is to analyze the value and prognostic significance of anti-CCP titer quantification in UA subjects.Methods: Serial anti-CCP assays were measured in 192 consecutive patients presenting with UA lasting less than 12 weeks. Clinical and serological data and arthritis outcome were evaluated every 6 months until two years of follow-up.Results: Anti-CCP positivity, at both low and high titer, and arthritis of hand joints significantly predicted RA at two years, risk increasing in subjects with high anti-CCP titers at baseline. Moreover, time to RA diagnosis was shorter in patients with high anti-CCP2 titers at enrollment with respect to those with low antibody concentration.Conclusions: Presence of anti-CCP antibodies, at both low and high concentration, is significantly associated with RA development in subjects with recent onset UA. However, time interval from the onset of the first symptoms to the fulfilment of the classification criteria appears to be directly related to the initial anti-CCP level.
AB - Introduction: The diagnostic, predictive and prognostic role of anti-cyclic citrullinated peptide (CCP) antibodies in rheumatoid arthritis (RA) patients is widely accepted. Moreover, detection of these antibodies in subjects presenting with undifferentiated arthritis (UA) is associated with a significant risk to develop the disease. On the other hand, clinical and prognostic significance of evaluating anti-CCP levels in subjects with inflammatory arthritis at disease onset has not been fully clarified. The goal of this prospective study is to analyze the value and prognostic significance of anti-CCP titer quantification in UA subjects.Methods: Serial anti-CCP assays were measured in 192 consecutive patients presenting with UA lasting less than 12 weeks. Clinical and serological data and arthritis outcome were evaluated every 6 months until two years of follow-up.Results: Anti-CCP positivity, at both low and high titer, and arthritis of hand joints significantly predicted RA at two years, risk increasing in subjects with high anti-CCP titers at baseline. Moreover, time to RA diagnosis was shorter in patients with high anti-CCP2 titers at enrollment with respect to those with low antibody concentration.Conclusions: Presence of anti-CCP antibodies, at both low and high concentration, is significantly associated with RA development in subjects with recent onset UA. However, time interval from the onset of the first symptoms to the fulfilment of the classification criteria appears to be directly related to the initial anti-CCP level.
UR - http://www.scopus.com/inward/record.url?scp=84872476490&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872476490&partnerID=8YFLogxK
U2 - 10.1186/ar4148
DO - 10.1186/ar4148
M3 - Article
C2 - 23339296
AN - SCOPUS:84872476490
VL - 15
JO - Arthritis Research and Therapy
JF - Arthritis Research and Therapy
SN - 1478-6354
IS - 1
M1 - R16
ER -