Anti-EGFR monoclonal antibody in cancer treatment: In vitro and in vivo evidence

Anna Elisa Quatrale, Daniela Petriella, Letizia Porcelli, Stefania Tommasi, Nicola Silvestris, Giuseppe Colucci, Angelo Paradiso, Amalia Azzariti

Research output: Contribution to journalArticlepeer-review

Abstract

The complexity of EGFR signaling network suggests that the receptor could be promising targets for new personalised therapy. In clinical practice two strategies targeting the receptor are available; they utilise monoclonal antibodies, directed towards the extracellular domain of EGFR, and small molecule tyrosine kinase inhibitors, which bind the catalytic kinase domain of the receptor. In this review, we summarise currently known pre-clinical data on the antitumor effects of monoclonal antibodies, which bind to EGFR in its inactive configuration, competing for ligand binding and thereby blocking ligand-induced EGFR tyrosine kinase activation. As a consequence of treatment, key EGFR-dependent intracellular signals in cancer cells are affected. Data explaining the mechanisms of action of anti-EGFR monoclonal antibodies, currently used in clinical setting and under development for the treatment of solid tumors, are revised with the aim to provide an overview of the most important preclinical studies showing the impact of this class of EGFR targeted agents on tumor biology.

Original languageEnglish
Pages (from-to)1973-1985
Number of pages13
JournalFrontiers in Bioscience
Volume16
Issue number5
DOIs
Publication statusPublished - Jan 1 2011

Keywords

  • Cetuximab
  • IMC-11F8
  • Matuzumab
  • Nimotuzumab
  • Panitumimab
  • Review
  • Zalutumumab

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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