Anti-epidermal growth factor receptor skin toxicity: A matter of topical hydration

Daris Ferrari, Carla Codecà, Barbara Bocci, Francesca Crepaldi, Martina Violati, Giulia Viale, Carmela Careri, Sarah Caldiera, Veronica Bordin, Andrea Luciani, Sabrina Zonato, Gabriela Cassinelli, Paolo Foa

Research output: Contribution to journalArticlepeer-review


Skin toxicity is a frequent complication of anti-epidermal growth factor receptor therapy, which can be an obstacle in maintaining the dose intensity and may negatively impact on the clinical outcome of cancer patients. Skin lesions depend on the disruption of the keratinocyte development pathways and no treatment is clearly effective in resolving the cutaneous alterations frequently found during antiepidermal growth factor receptor therapy. Among systemic treatments, oral tetracycline proved to be useful in preventing skin manifestations. We describe the case of a patient affected by metastatic colorectal cancer, for whom a combination of chemotherapy and cetuximab was used as second-line treatment. The patient developed a symptomatic papulopustular skin rash that disappeared completely after a twice-daily application of a hydrating and moisturizing cream, mainly consisting of a mixture of paraffin, silicone compounds, and macrogol. The marked cutaneous amelioration allowed the patient to continue cetuximab without any further symptoms and was associated with a partial radiological response.

Original languageEnglish
Pages (from-to)144-146
Number of pages3
JournalAnti-Cancer Drugs
Issue number2
Publication statusPublished - Feb 1 2016


  • Cetuximab
  • Hydrating cream
  • Skin toxicity

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Cancer Research
  • Oncology


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