Anti-ganglioside antibodies in coeliac disease with neurological disorders

U. Volta, R. De Giorgio, A. Granito, V. Stanghellini, G. Barbara, P. Avoni, R. Liguori, N. Petrolini, E. Fiorini, P. Montagna, R. Corinaldesi, F. B. Bianchi

Research output: Contribution to journalArticle

Abstract

Background: Anti-ganglioside antibodies have been described in sera of coeliac patients with peripheral neuropathy and cerebellar ataxia. Aims: To investigate the correlation between anti-ganglioside antibodies and neurological involvement in coeliac disease before and after gluten-free diet. Patients and methods: Twenty-two untreated coeliac patients with neurological dysfunction and 30 untreated coeliacs without neurological dysfunction, 20 patients with neurological disorders, 50 autoimmune disease and 20 blood donors were tested for anti-GM1, anti-GD1b and anti-GQ1b IgG and IgM antibodies by enzyme-linked immunosorbent assay. Results: IgG antibodies to at least one of the three antigens tested were positive in 64% of coeliac patients with neurological symptoms compared to 30% of coeliacs without neurological dysfunction (P = 0.02), 50% of patients with neurological disorders (P = ns), 20% with autoimmune diseases (P = 0.003) and none of blood donors (P = 0.0001). A strict gluten-free diet determined anti-ganglioside antibody disappearance in about half of coeliacs. Conclusions: A significant correlation between anti-ganglioside antibodies and neurological disorders in patients with an underlying coeliac disease has been found. Anti-ganglioside antibodies may represent a new immunological marker to identify neurological impairment in patients with coeliac disease.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalDigestive and Liver Disease
Volume38
Issue number3
DOIs
Publication statusPublished - Mar 2006

Fingerprint

Gangliosides
Celiac Disease
Nervous System Diseases
Anti-Idiotypic Antibodies
Abdomen
Gluten-Free Diet
Blood Donors
Autoimmune Diseases
Cerebellar Ataxia
Antibodies
Peripheral Nervous System Diseases
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Antigens
Serum

Keywords

  • Anti-ganglioside antibodies
  • Coeliac disease
  • Neurological disorders
  • Neuronal antibodies

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Volta, U., De Giorgio, R., Granito, A., Stanghellini, V., Barbara, G., Avoni, P., ... Bianchi, F. B. (2006). Anti-ganglioside antibodies in coeliac disease with neurological disorders. Digestive and Liver Disease, 38(3), 183-187. https://doi.org/10.1016/j.dld.2005.11.013

Anti-ganglioside antibodies in coeliac disease with neurological disorders. / Volta, U.; De Giorgio, R.; Granito, A.; Stanghellini, V.; Barbara, G.; Avoni, P.; Liguori, R.; Petrolini, N.; Fiorini, E.; Montagna, P.; Corinaldesi, R.; Bianchi, F. B.

In: Digestive and Liver Disease, Vol. 38, No. 3, 03.2006, p. 183-187.

Research output: Contribution to journalArticle

Volta, U, De Giorgio, R, Granito, A, Stanghellini, V, Barbara, G, Avoni, P, Liguori, R, Petrolini, N, Fiorini, E, Montagna, P, Corinaldesi, R & Bianchi, FB 2006, 'Anti-ganglioside antibodies in coeliac disease with neurological disorders', Digestive and Liver Disease, vol. 38, no. 3, pp. 183-187. https://doi.org/10.1016/j.dld.2005.11.013
Volta, U. ; De Giorgio, R. ; Granito, A. ; Stanghellini, V. ; Barbara, G. ; Avoni, P. ; Liguori, R. ; Petrolini, N. ; Fiorini, E. ; Montagna, P. ; Corinaldesi, R. ; Bianchi, F. B. / Anti-ganglioside antibodies in coeliac disease with neurological disorders. In: Digestive and Liver Disease. 2006 ; Vol. 38, No. 3. pp. 183-187.
@article{d5f2fa52ea784fcab1cb75fe282bdf6f,
title = "Anti-ganglioside antibodies in coeliac disease with neurological disorders",
abstract = "Background: Anti-ganglioside antibodies have been described in sera of coeliac patients with peripheral neuropathy and cerebellar ataxia. Aims: To investigate the correlation between anti-ganglioside antibodies and neurological involvement in coeliac disease before and after gluten-free diet. Patients and methods: Twenty-two untreated coeliac patients with neurological dysfunction and 30 untreated coeliacs without neurological dysfunction, 20 patients with neurological disorders, 50 autoimmune disease and 20 blood donors were tested for anti-GM1, anti-GD1b and anti-GQ1b IgG and IgM antibodies by enzyme-linked immunosorbent assay. Results: IgG antibodies to at least one of the three antigens tested were positive in 64{\%} of coeliac patients with neurological symptoms compared to 30{\%} of coeliacs without neurological dysfunction (P = 0.02), 50{\%} of patients with neurological disorders (P = ns), 20{\%} with autoimmune diseases (P = 0.003) and none of blood donors (P = 0.0001). A strict gluten-free diet determined anti-ganglioside antibody disappearance in about half of coeliacs. Conclusions: A significant correlation between anti-ganglioside antibodies and neurological disorders in patients with an underlying coeliac disease has been found. Anti-ganglioside antibodies may represent a new immunological marker to identify neurological impairment in patients with coeliac disease.",
keywords = "Anti-ganglioside antibodies, Coeliac disease, Neurological disorders, Neuronal antibodies",
author = "U. Volta and {De Giorgio}, R. and A. Granito and V. Stanghellini and G. Barbara and P. Avoni and R. Liguori and N. Petrolini and E. Fiorini and P. Montagna and R. Corinaldesi and Bianchi, {F. B.}",
year = "2006",
month = "3",
doi = "10.1016/j.dld.2005.11.013",
language = "English",
volume = "38",
pages = "183--187",
journal = "Digestive and Liver Disease",
issn = "1590-8658",
publisher = "Elsevier B.V.",
number = "3",

}

TY - JOUR

T1 - Anti-ganglioside antibodies in coeliac disease with neurological disorders

AU - Volta, U.

AU - De Giorgio, R.

AU - Granito, A.

AU - Stanghellini, V.

AU - Barbara, G.

AU - Avoni, P.

AU - Liguori, R.

AU - Petrolini, N.

AU - Fiorini, E.

AU - Montagna, P.

AU - Corinaldesi, R.

AU - Bianchi, F. B.

PY - 2006/3

Y1 - 2006/3

N2 - Background: Anti-ganglioside antibodies have been described in sera of coeliac patients with peripheral neuropathy and cerebellar ataxia. Aims: To investigate the correlation between anti-ganglioside antibodies and neurological involvement in coeliac disease before and after gluten-free diet. Patients and methods: Twenty-two untreated coeliac patients with neurological dysfunction and 30 untreated coeliacs without neurological dysfunction, 20 patients with neurological disorders, 50 autoimmune disease and 20 blood donors were tested for anti-GM1, anti-GD1b and anti-GQ1b IgG and IgM antibodies by enzyme-linked immunosorbent assay. Results: IgG antibodies to at least one of the three antigens tested were positive in 64% of coeliac patients with neurological symptoms compared to 30% of coeliacs without neurological dysfunction (P = 0.02), 50% of patients with neurological disorders (P = ns), 20% with autoimmune diseases (P = 0.003) and none of blood donors (P = 0.0001). A strict gluten-free diet determined anti-ganglioside antibody disappearance in about half of coeliacs. Conclusions: A significant correlation between anti-ganglioside antibodies and neurological disorders in patients with an underlying coeliac disease has been found. Anti-ganglioside antibodies may represent a new immunological marker to identify neurological impairment in patients with coeliac disease.

AB - Background: Anti-ganglioside antibodies have been described in sera of coeliac patients with peripheral neuropathy and cerebellar ataxia. Aims: To investigate the correlation between anti-ganglioside antibodies and neurological involvement in coeliac disease before and after gluten-free diet. Patients and methods: Twenty-two untreated coeliac patients with neurological dysfunction and 30 untreated coeliacs without neurological dysfunction, 20 patients with neurological disorders, 50 autoimmune disease and 20 blood donors were tested for anti-GM1, anti-GD1b and anti-GQ1b IgG and IgM antibodies by enzyme-linked immunosorbent assay. Results: IgG antibodies to at least one of the three antigens tested were positive in 64% of coeliac patients with neurological symptoms compared to 30% of coeliacs without neurological dysfunction (P = 0.02), 50% of patients with neurological disorders (P = ns), 20% with autoimmune diseases (P = 0.003) and none of blood donors (P = 0.0001). A strict gluten-free diet determined anti-ganglioside antibody disappearance in about half of coeliacs. Conclusions: A significant correlation between anti-ganglioside antibodies and neurological disorders in patients with an underlying coeliac disease has been found. Anti-ganglioside antibodies may represent a new immunological marker to identify neurological impairment in patients with coeliac disease.

KW - Anti-ganglioside antibodies

KW - Coeliac disease

KW - Neurological disorders

KW - Neuronal antibodies

UR - http://www.scopus.com/inward/record.url?scp=33746092134&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746092134&partnerID=8YFLogxK

U2 - 10.1016/j.dld.2005.11.013

DO - 10.1016/j.dld.2005.11.013

M3 - Article

C2 - 16458087

AN - SCOPUS:33746092134

VL - 38

SP - 183

EP - 187

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

SN - 1590-8658

IS - 3

ER -