Anti-GM1, IgM antibodies in motor neuron disease and neuropathy

E. Nobile-Orazio, M. Carpo, G. Legname, N. Meucci, S. Sonnino, G. Scarlato

Research output: Contribution to journalArticlepeer-review


We found anti-GM1, IgM antibodies in 23% of 56 patients with motor neuron disease (MND), in 19% of 69 patients with neuropathy, and in 7% of 107 controls with other neurologic and nonneurologic diseases. Most of these patients had anti-GM1, IgM antibody titers of 1: 80 or less; slightly higher antibody titers (up to 1: 640) were found in 3 patients, 1 with MND and 2 with neuropathy, and very high titers (1: 20,480) in a patient with MND and an IgMK M protein that reacted with GM1, GD1b,, and asialo GM,. Six other patients with anti-GM1, IgM had serum IgM that also bound to GDlb Reactivity with GD1b, did not correlate with anti-GM1, titers but was only present in patients with MND or neuropathy. Anti-GM1, IgM antibodies may be a normal constituent of the human antibody repertoire but their frequency and, in some cases, their levels are higher in patients with MND and neuropathy. The origin and the pathogenetic role of these antibodies in neural impairment remain to be established.

Original languageEnglish
Pages (from-to)1747-1750
Number of pages4
Issue number11
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)


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