Anti-HCV antibodies and hepatocellular carcinoma. Relationship in a medium-risk population.

C. Porta, M. Moroni, G. Nastasi, G. Ricci, I. Casagranda

Research output: Contribution to journalArticlepeer-review


By means of an accurate immunoenzymatic assay, the prevalence was studied of antibodies to hepatitis C virus (HCV) in three different populations: 74 patients affected with hepatocellular carcinoma (HCC) on preexisting cirrhosis, 82 patients with liver cirrhosis but with no apparent neoplasm, and 70 control subjects, hospitalized for various conditions, of internal medicine or geriatric interest. 70.2% of HCC patients exhibited anti-HBC antibodies, versus 47.5% of cirrhotic subjects with no tumor and 7.1% of controls. Such results suggest the possible role of HCV in the etiopathogenesis of HCC, and its possible synergy with other agents-e.g., hepatitis B virus, alcohol--in causing chronically injured hepatocytes to become neoplastic.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalUpsala Journal of Medical Sciences
Issue number3
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Medicine(all)


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