Anti-HCV antibodies in patients with chronic liver disease and different amounts of alcohol intake: A multivariate analysis

Marco Tabone, Giovanni Galatola, Giovanni Corrao, Sarino Aricó

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the association between the mean daily alcohol intake and positivity for serum anti-hepatitis C virus antibodies in patients with chronic liver disease of varying severity. To test the hypothesis that alcohol intake and hepatitis C virus infection have an independent role in determining chronic liver disease. Design: Retrospective study using a multivariate analysis model. Methods: In 212 consecutive patients with chronic liver disease, serum anti-hepatitis C virus antibodies were detected using a second-generation test and recombinant immunoblotting assay. The lifetime mean daily alcohol intake was measured by a standardized questionnaire. Patients were subsequently divided according to the histological presence or absence of liver cirrhosis and stratified into progressive categories of alcohol intake. The dose-effect relationship between anti-hepatitis C virus status and mean daily alcohol intake was assessed by a model of unconditional logistic regression, where age, gender, degree of severity of liver disease and chronic hepatitis B virus infection were considered as covariates. Results: There was a strong negative association between the mean daily alcohol intake and the presence of anti-hepatitis C virus antibodies, with odds ratio decreasing down to 0.01 for the category of highest alcohol intake; no association was found for the other variables considered. Our data support the hypothesis that alcohol intake and infection with hepatitis viruses are independent determinants of chronic liver disease.

Original languageEnglish
Pages (from-to)749-754
Number of pages6
JournalEuropean Journal of Gastroenterology and Hepatology
Volume5
Issue number9
Publication statusPublished - 1993

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Keywords

  • Alcoholic liver disease
  • Hepatitis C virus
  • Multivariate analysis

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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