Objective: To investigate the association between the mean daily alcohol intake and positivity for serum anti-hepatitis C virus antibodies in patients with chronic liver disease of varying severity. To test the hypothesis that alcohol intake and hepatitis C virus infection have an independent role in determining chronic liver disease. Design: Retrospective study using a multivariate analysis model. Methods: In 212 consecutive patients with chronic liver disease, serum anti-hepatitis C virus antibodies were detected using a second-generation test and recombinant immunoblotting assay. The lifetime mean daily alcohol intake was measured by a standardized questionnaire. Patients were subsequently divided according to the histological presence or absence of liver cirrhosis and stratified into progressive categories of alcohol intake. The dose-effect relationship between anti-hepatitis C virus status and mean daily alcohol intake was assessed by a model of unconditional logistic regression, where age, gender, degree of severity of liver disease and chronic hepatitis B virus infection were considered as covariates. Results: There was a strong negative association between the mean daily alcohol intake and the presence of anti-hepatitis C virus antibodies, with odds ratio decreasing down to 0.01 for the category of highest alcohol intake; no association was found for the other variables considered. Our data support the hypothesis that alcohol intake and infection with hepatitis viruses are independent determinants of chronic liver disease.
|Number of pages||6|
|Journal||European Journal of Gastroenterology and Hepatology|
|Publication status||Published - 1993|
- Alcoholic liver disease
- Hepatitis C virus
- Multivariate analysis
ASJC Scopus subject areas