Abstract
Aim: Analysis of the prevalence of serum IgM antibodies directed against the HCV-core antigen (HCV-IgM) in patients with Porphyria cutanea tarda (PCT), taking into account the hepatic histological picture, liver biochemical markers and the PCT biochemical indices. Background: Hepatic damage, especially that due to HCV infection, has been previously reported as a PCT trigger. HCV-IgM reactivity, a marker of chronic HCV hepatitis, suggested to be related to active virus replication could also be related to the PCT clinical course. Methods: Blood samples of 97 patients, previously analyzed for a panel of clinical, histological and laboratory variables, followed in our Centre for Porphyria, stored at -80°C, were available to be retrospectively assayed for anti-HCV-core IgM (HCV-IgM, ELISA). Results: 61% HCV-IgM positivity was found, with no apparent significant relationship with the respective histological hepatitis classification, PCT remission phase, and PCT familiarity, when evaluated on overall patients. The levels of HCV-IgM presented a peculiar behaviour when correlated to the serum AST values. In fact, there was a significant positive correlation in those with HCV-IgM <4 and a not significant, inverse correlation in the remaining group. These two groups showed other differences: the HCV-IgM levels were correlated to histology, PCT remission and to the markers of liver disease (such as AST and ALT) only in the first group. Conclusion: a relationship between IgM response, PCT activity and the underlying liver disease is suggested.
| Original language | English |
|---|---|
| Pages (from-to) | 226-231 |
| Number of pages | 6 |
| Journal | Journal of the European Academy of Dermatology and Venereology |
| Volume | 6 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1996 |
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Keywords
- Anti-HCV-Core-IgM
- Chronic hepatitis
- PCT
ASJC Scopus subject areas
- Dermatology
- Infectious Diseases
Cite this
Anti-HCV-core specific IgM in porphyria cutanea tarda. / D'Alessandro Gandolfo, Luciana; Ameglio, Franco; Biolcati, Gianfranco; Pimpinelli, Fulvia; Trento, Elisabetta; Galante, Marisa; Nardi, Armande; Topi, Giancarlo.
In: Journal of the European Academy of Dermatology and Venereology, Vol. 6, No. 3, 1996, p. 226-231.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anti-HCV-core specific IgM in porphyria cutanea tarda
AU - D'Alessandro Gandolfo, Luciana
AU - Ameglio, Franco
AU - Biolcati, Gianfranco
AU - Pimpinelli, Fulvia
AU - Trento, Elisabetta
AU - Galante, Marisa
AU - Nardi, Armande
AU - Topi, Giancarlo
PY - 1996
Y1 - 1996
N2 - Aim: Analysis of the prevalence of serum IgM antibodies directed against the HCV-core antigen (HCV-IgM) in patients with Porphyria cutanea tarda (PCT), taking into account the hepatic histological picture, liver biochemical markers and the PCT biochemical indices. Background: Hepatic damage, especially that due to HCV infection, has been previously reported as a PCT trigger. HCV-IgM reactivity, a marker of chronic HCV hepatitis, suggested to be related to active virus replication could also be related to the PCT clinical course. Methods: Blood samples of 97 patients, previously analyzed for a panel of clinical, histological and laboratory variables, followed in our Centre for Porphyria, stored at -80°C, were available to be retrospectively assayed for anti-HCV-core IgM (HCV-IgM, ELISA). Results: 61% HCV-IgM positivity was found, with no apparent significant relationship with the respective histological hepatitis classification, PCT remission phase, and PCT familiarity, when evaluated on overall patients. The levels of HCV-IgM presented a peculiar behaviour when correlated to the serum AST values. In fact, there was a significant positive correlation in those with HCV-IgM <4 and a not significant, inverse correlation in the remaining group. These two groups showed other differences: the HCV-IgM levels were correlated to histology, PCT remission and to the markers of liver disease (such as AST and ALT) only in the first group. Conclusion: a relationship between IgM response, PCT activity and the underlying liver disease is suggested.
AB - Aim: Analysis of the prevalence of serum IgM antibodies directed against the HCV-core antigen (HCV-IgM) in patients with Porphyria cutanea tarda (PCT), taking into account the hepatic histological picture, liver biochemical markers and the PCT biochemical indices. Background: Hepatic damage, especially that due to HCV infection, has been previously reported as a PCT trigger. HCV-IgM reactivity, a marker of chronic HCV hepatitis, suggested to be related to active virus replication could also be related to the PCT clinical course. Methods: Blood samples of 97 patients, previously analyzed for a panel of clinical, histological and laboratory variables, followed in our Centre for Porphyria, stored at -80°C, were available to be retrospectively assayed for anti-HCV-core IgM (HCV-IgM, ELISA). Results: 61% HCV-IgM positivity was found, with no apparent significant relationship with the respective histological hepatitis classification, PCT remission phase, and PCT familiarity, when evaluated on overall patients. The levels of HCV-IgM presented a peculiar behaviour when correlated to the serum AST values. In fact, there was a significant positive correlation in those with HCV-IgM <4 and a not significant, inverse correlation in the remaining group. These two groups showed other differences: the HCV-IgM levels were correlated to histology, PCT remission and to the markers of liver disease (such as AST and ALT) only in the first group. Conclusion: a relationship between IgM response, PCT activity and the underlying liver disease is suggested.
KW - Anti-HCV-Core-IgM
KW - Chronic hepatitis
KW - PCT
UR - http://www.scopus.com/inward/record.url?scp=8944231157&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=8944231157&partnerID=8YFLogxK
U2 - 10.1016/0926-9959(95)00164-6
DO - 10.1016/0926-9959(95)00164-6
M3 - Article
AN - SCOPUS:8944231157
VL - 6
SP - 226
EP - 231
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
SN - 0926-9959
IS - 3
ER -