Anti-HCV tests prepared with recombinant and synthetic antigens for the monitoring of response to interferon therapy in chronic hepatitis

G. C. Icardi, P. Bonanni, A. Picciotto, G. Varagona, R. Bandettini, M. Rebora, A. M. Raffo

Research output: Contribution to journalArticlepeer-review

Abstract

The patterns of reactivity to 9 ELISA tests and 2 Line-based immunoassays for the detection of antibodies to the Hepatitis C virus were evaluated during and after interferon therapy in 13 patients affected with HCV-related chronic liver disease. Out of the 5 long-term responders to the treatment, 3 had an initial complete pattern of reactivity to RIBA HCV 2nd Generation. These patients showed a slow but constant decrease of the reactivities to the non-structural c-100 and NS4-NS5 encoded antigens, both of recombinant and synthetic origin. Our data suggest how subjects with a complete RIBA HCV pattern at the beginning of therapy with alpha-interferon could be usefully followed up with such supplemental tests in order to predict the duration of the response to antiviral treatment.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalJournal of Preventive Medicine and Hygiene
Volume35
Issue number3-4
Publication statusPublished - 1994

Keywords

  • anti-HCV
  • interferon therapy
  • polymerase chain reaction
  • recombinant antigens
  • synthetic peptides

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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