Abstract
The patterns of reactivity to 9 ELISA tests and 2 Line-based immunoassays for the detection of antibodies to the Hepatitis C virus were evaluated during and after interferon therapy in 13 patients affected with HCV-related chronic liver disease. Out of the 5 long-term responders to the treatment, 3 had an initial complete pattern of reactivity to RIBA HCV 2nd Generation. These patients showed a slow but constant decrease of the reactivities to the non-structural c-100 and NS4-NS5 encoded antigens, both of recombinant and synthetic origin. Our data suggest how subjects with a complete RIBA HCV pattern at the beginning of therapy with alpha-interferon could be usefully followed up with such supplemental tests in order to predict the duration of the response to antiviral treatment.
Original language | English |
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Pages (from-to) | 145-148 |
Number of pages | 4 |
Journal | Journal of Preventive Medicine and Hygiene |
Volume | 35 |
Issue number | 3-4 |
Publication status | Published - 1994 |
Keywords
- anti-HCV
- interferon therapy
- polymerase chain reaction
- recombinant antigens
- synthetic peptides
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health