Anti-HCV tests prepared with recombinant and synthetic antigens for the monitoring of response to interferon therapy in chronic hepatitis

G. C. Icardi; P. Bonanni; A. Picciotto; G. Varagona; R. Bandettini; M. Rebora; A. M. Raffo

Anti-HCV tests prepared with recombinant and synthetic antigens for the monitoring of response to interferon therapy in chronic hepatitis

G. C. Icardi, P. Bonanni, A. Picciotto, G. Varagona, R. Bandettini, M. Rebora, A. M. Raffo

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

The patterns of reactivity to 9 ELISA tests and 2 Line-based immunoassays for the detection of antibodies to the Hepatitis C virus were evaluated during and after interferon therapy in 13 patients affected with HCV-related chronic liver disease. Out of the 5 long-term responders to the treatment, 3 had an initial complete pattern of reactivity to RIBA HCV 2nd Generation. These patients showed a slow but constant decrease of the reactivities to the non-structural c-100 and NS4-NS5 encoded antigens, both of recombinant and synthetic origin. Our data suggest how subjects with a complete RIBA HCV pattern at the beginning of therapy with alpha-interferon could be usefully followed up with such supplemental tests in order to predict the duration of the response to antiviral treatment.

Original language	English
Pages (from-to)	145-148
Number of pages	4
Journal	Journal of Preventive Medicine and Hygiene
Volume	35
Issue number	3-4
Publication status	Published - 1994

Keywords

anti-HCV
interferon therapy
polymerase chain reaction
recombinant antigens
synthetic peptides

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

Cite this

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title = "Anti-HCV tests prepared with recombinant and synthetic antigens for the monitoring of response to interferon therapy in chronic hepatitis",

abstract = "The patterns of reactivity to 9 ELISA tests and 2 Line-based immunoassays for the detection of antibodies to the Hepatitis C virus were evaluated during and after interferon therapy in 13 patients affected with HCV-related chronic liver disease. Out of the 5 long-term responders to the treatment, 3 had an initial complete pattern of reactivity to RIBA HCV 2nd Generation. These patients showed a slow but constant decrease of the reactivities to the non-structural c-100 and NS4-NS5 encoded antigens, both of recombinant and synthetic origin. Our data suggest how subjects with a complete RIBA HCV pattern at the beginning of therapy with alpha-interferon could be usefully followed up with such supplemental tests in order to predict the duration of the response to antiviral treatment.",

keywords = "anti-HCV, interferon therapy, polymerase chain reaction, recombinant antigens, synthetic peptides",

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TY - JOUR

T1 - Anti-HCV tests prepared with recombinant and synthetic antigens for the monitoring of response to interferon therapy in chronic hepatitis

AU - Icardi, G. C.

AU - Bonanni, P.

AU - Picciotto, A.

AU - Varagona, G.

AU - Bandettini, R.

AU - Rebora, M.

AU - Raffo, A. M.

PY - 1994

Y1 - 1994

N2 - The patterns of reactivity to 9 ELISA tests and 2 Line-based immunoassays for the detection of antibodies to the Hepatitis C virus were evaluated during and after interferon therapy in 13 patients affected with HCV-related chronic liver disease. Out of the 5 long-term responders to the treatment, 3 had an initial complete pattern of reactivity to RIBA HCV 2nd Generation. These patients showed a slow but constant decrease of the reactivities to the non-structural c-100 and NS4-NS5 encoded antigens, both of recombinant and synthetic origin. Our data suggest how subjects with a complete RIBA HCV pattern at the beginning of therapy with alpha-interferon could be usefully followed up with such supplemental tests in order to predict the duration of the response to antiviral treatment.

AB - The patterns of reactivity to 9 ELISA tests and 2 Line-based immunoassays for the detection of antibodies to the Hepatitis C virus were evaluated during and after interferon therapy in 13 patients affected with HCV-related chronic liver disease. Out of the 5 long-term responders to the treatment, 3 had an initial complete pattern of reactivity to RIBA HCV 2nd Generation. These patients showed a slow but constant decrease of the reactivities to the non-structural c-100 and NS4-NS5 encoded antigens, both of recombinant and synthetic origin. Our data suggest how subjects with a complete RIBA HCV pattern at the beginning of therapy with alpha-interferon could be usefully followed up with such supplemental tests in order to predict the duration of the response to antiviral treatment.

KW - anti-HCV

KW - interferon therapy

KW - polymerase chain reaction

KW - recombinant antigens

KW - synthetic peptides

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Anti-HCV tests prepared with recombinant and synthetic antigens for the monitoring of response to interferon therapy in chronic hepatitis

Abstract

Keywords

ASJC Scopus subject areas

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