Ricerca anticorpi anti-HLA (Ab1) e anticorpi antiidiotipo (Ab2) diretti verso Ab1 anti-HLA in diversi preparati di immunoglobuline polispecifiche ad uso endovenoso.

Translated title of the contribution: Anti-HLA antibodies (Ab1) and anti-idiotypic antibodies (Ab2) directed against Anti-HLA Ab1 in various preparations of polyspecific immunoglobulins for intravenous use

S. Barocci, D. Fenoglio, A. Leprini, A. Nocera

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3 Citations (Scopus)

Abstract

In this study, different intravenous immunoglobulin infusions (I.V. Ig.), were analyzed for the presence of either anti-HLA antibodies (Ab1) or anti-idiotypic antibodies (Ab2) directed against Ab1 anti-HLA. No evidence of either antibody types was found in tested I.V. Ig. preparations. Because of the absence of Ab1 anti-HLA, prophylactic and/or therapeutic use of I.V. Ig. appears safe in patients waiting for organ graft or in transplanted patients. The lack of Ab2 anti-Ab1 anti-HLA makes worthless the utilization of such preparations for neutralization of Ab1 present in highly sensitized dialysis patients or suppression of their production in transplanted patients in contrast with the previous reports suggesting this possibility.

Original languageItalian
Pages (from-to)1193-1200
Number of pages8
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume66
Issue number12
Publication statusPublished - Dec 1990

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Intravenous Immunoglobulins
Anti-Idiotypic Antibodies
Intravenous Infusions
Therapeutic Uses
Dialysis
Transplants
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Ricerca anticorpi anti-HLA (Ab1) e anticorpi antiidiotipo (Ab2) diretti verso Ab1 anti-HLA in diversi preparati di immunoglobuline polispecifiche ad uso endovenoso.",
abstract = "In this study, different intravenous immunoglobulin infusions (I.V. Ig.), were analyzed for the presence of either anti-HLA antibodies (Ab1) or anti-idiotypic antibodies (Ab2) directed against Ab1 anti-HLA. No evidence of either antibody types was found in tested I.V. Ig. preparations. Because of the absence of Ab1 anti-HLA, prophylactic and/or therapeutic use of I.V. Ig. appears safe in patients waiting for organ graft or in transplanted patients. The lack of Ab2 anti-Ab1 anti-HLA makes worthless the utilization of such preparations for neutralization of Ab1 present in highly sensitized dialysis patients or suppression of their production in transplanted patients in contrast with the previous reports suggesting this possibility.",
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AU - Barocci, S.

AU - Fenoglio, D.

AU - Leprini, A.

AU - Nocera, A.

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