Abstract
α-melanocyte-stimulating hormone (α-MSH) is an endogenous neuroimmunomodulatory peptide that inhibits fever and all major forms of experimental inflammation. In humans, concentrations of α-MSH are increased at sites of inflammation, and in plasma in inflammatory disorders and after injection of endotoxin. The effects of this 'anti-cytokine' peptide are mediated through α-MSH receptors and regulatory circuits in macrophages and neutrophils, and through descending neural anti-inflammatory pathways that originate from α-MSH receptors on neurons within the brain.
| Original language | English |
|---|---|
| Pages (from-to) | 140-145 |
| Number of pages | 6 |
| Journal | Immunology Today |
| Volume | 18 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1997 |
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ASJC Scopus subject areas
- Immunology
Cite this
Anti-inflammatory actions of the neuroimmunomodulator α-MSH. / Lipton, James M.; Catania, Anna.
In: Immunology Today, Vol. 18, No. 3, 03.1997, p. 140-145.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anti-inflammatory actions of the neuroimmunomodulator α-MSH
AU - Lipton, James M.
AU - Catania, Anna
PY - 1997/3
Y1 - 1997/3
N2 - α-melanocyte-stimulating hormone (α-MSH) is an endogenous neuroimmunomodulatory peptide that inhibits fever and all major forms of experimental inflammation. In humans, concentrations of α-MSH are increased at sites of inflammation, and in plasma in inflammatory disorders and after injection of endotoxin. The effects of this 'anti-cytokine' peptide are mediated through α-MSH receptors and regulatory circuits in macrophages and neutrophils, and through descending neural anti-inflammatory pathways that originate from α-MSH receptors on neurons within the brain.
AB - α-melanocyte-stimulating hormone (α-MSH) is an endogenous neuroimmunomodulatory peptide that inhibits fever and all major forms of experimental inflammation. In humans, concentrations of α-MSH are increased at sites of inflammation, and in plasma in inflammatory disorders and after injection of endotoxin. The effects of this 'anti-cytokine' peptide are mediated through α-MSH receptors and regulatory circuits in macrophages and neutrophils, and through descending neural anti-inflammatory pathways that originate from α-MSH receptors on neurons within the brain.
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UR - http://www.scopus.com/inward/citedby.url?scp=0031106466&partnerID=8YFLogxK
U2 - 10.1016/S0167-5699(97)01009-8
DO - 10.1016/S0167-5699(97)01009-8
M3 - Article
C2 - 9078687
AN - SCOPUS:0031106466
VL - 18
SP - 140
EP - 145
JO - Immunology Today
JF - Immunology Today
SN - 0167-5699
IS - 3
ER -