Anti-inflammatory actions of the neuroimmunomodulator α-MSH

James M. Lipton, Anna Catania

Research output: Contribution to journalArticlepeer-review


α-melanocyte-stimulating hormone (α-MSH) is an endogenous neuroimmunomodulatory peptide that inhibits fever and all major forms of experimental inflammation. In humans, concentrations of α-MSH are increased at sites of inflammation, and in plasma in inflammatory disorders and after injection of endotoxin. The effects of this 'anti-cytokine' peptide are mediated through α-MSH receptors and regulatory circuits in macrophages and neutrophils, and through descending neural anti-inflammatory pathways that originate from α-MSH receptors on neurons within the brain.

Original languageEnglish
Pages (from-to)140-145
Number of pages6
JournalImmunology Today
Issue number3
Publication statusPublished - Mar 1997

ASJC Scopus subject areas

  • Immunology


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