Anti-inflammatory actions of the neuroimmunomodulator α-MSH

James M. Lipton, Anna Catania

Research output: Contribution to journalArticle

Abstract

α-melanocyte-stimulating hormone (α-MSH) is an endogenous neuroimmunomodulatory peptide that inhibits fever and all major forms of experimental inflammation. In humans, concentrations of α-MSH are increased at sites of inflammation, and in plasma in inflammatory disorders and after injection of endotoxin. The effects of this 'anti-cytokine' peptide are mediated through α-MSH receptors and regulatory circuits in macrophages and neutrophils, and through descending neural anti-inflammatory pathways that originate from α-MSH receptors on neurons within the brain.

Original languageEnglish
Pages (from-to)140-145
Number of pages6
JournalImmunology Today
Volume18
Issue number3
DOIs
Publication statusPublished - Mar 1997

Fingerprint

Melanocyte-Stimulating Hormones
Anti-Inflammatory Agents
Inflammation
Peptides
Endotoxins
Neutrophils
Fever
Macrophages
Cytokines
Neurons
Injections
Brain
MSH receptor

ASJC Scopus subject areas

  • Immunology

Cite this

Anti-inflammatory actions of the neuroimmunomodulator α-MSH. / Lipton, James M.; Catania, Anna.

In: Immunology Today, Vol. 18, No. 3, 03.1997, p. 140-145.

Research output: Contribution to journalArticle

Lipton, James M. ; Catania, Anna. / Anti-inflammatory actions of the neuroimmunomodulator α-MSH. In: Immunology Today. 1997 ; Vol. 18, No. 3. pp. 140-145.
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