Abstract
Tocotrienols (T3) have been shown to represent a very important part of the vitamin E family since they have opened new opportunities to prevent or treat a multitude of age-related chronic diseases. The beneficial effects of T3 include the amelioration of lipid profile, the promotion of Nrf2 mediated cytoprotective activity and the suppression of inflammation. All these effects may be the consequence of the ability of T3 to target multiple pathways. We here propose that these effects may be the result of a single target of T3, namely senescent cells. Indeed, T3 may act by a direct suppression of the senescence-associated secretory phenotype (SASP) produced by senescent cells, mediated by inhibition of NF-kB and mTOR, or may potentially remove the origin of the SASP trough senolysis (selective death of senescent cells). Further studies addressed to investigate the impact of T3 on cellular senescence "in vitro" as well as in experimental models of age-related diseases "in vivo" are clearly encouraged.
| Original language | English |
|---|---|
| Article number | 22 |
| Journal | Biological Procedures Online |
| Volume | 20 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Nov 20 2018 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies : A SASPected Involvement of Cellular Senescence. / Malavolta, Marco; Pierpaoli, Elisa; Giacconi, Robertina; Basso, Andrea; Cardelli, Maurizio; Piacenza, Francesco; Provinciali, Mauro.
In: Biological Procedures Online, Vol. 20, No. 1, 22, 20.11.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies
T2 - A SASPected Involvement of Cellular Senescence
AU - Malavolta, Marco
AU - Pierpaoli, Elisa
AU - Giacconi, Robertina
AU - Basso, Andrea
AU - Cardelli, Maurizio
AU - Piacenza, Francesco
AU - Provinciali, Mauro
PY - 2018/11/20
Y1 - 2018/11/20
N2 - Tocotrienols (T3) have been shown to represent a very important part of the vitamin E family since they have opened new opportunities to prevent or treat a multitude of age-related chronic diseases. The beneficial effects of T3 include the amelioration of lipid profile, the promotion of Nrf2 mediated cytoprotective activity and the suppression of inflammation. All these effects may be the consequence of the ability of T3 to target multiple pathways. We here propose that these effects may be the result of a single target of T3, namely senescent cells. Indeed, T3 may act by a direct suppression of the senescence-associated secretory phenotype (SASP) produced by senescent cells, mediated by inhibition of NF-kB and mTOR, or may potentially remove the origin of the SASP trough senolysis (selective death of senescent cells). Further studies addressed to investigate the impact of T3 on cellular senescence "in vitro" as well as in experimental models of age-related diseases "in vivo" are clearly encouraged.
AB - Tocotrienols (T3) have been shown to represent a very important part of the vitamin E family since they have opened new opportunities to prevent or treat a multitude of age-related chronic diseases. The beneficial effects of T3 include the amelioration of lipid profile, the promotion of Nrf2 mediated cytoprotective activity and the suppression of inflammation. All these effects may be the consequence of the ability of T3 to target multiple pathways. We here propose that these effects may be the result of a single target of T3, namely senescent cells. Indeed, T3 may act by a direct suppression of the senescence-associated secretory phenotype (SASP) produced by senescent cells, mediated by inhibition of NF-kB and mTOR, or may potentially remove the origin of the SASP trough senolysis (selective death of senescent cells). Further studies addressed to investigate the impact of T3 on cellular senescence "in vitro" as well as in experimental models of age-related diseases "in vivo" are clearly encouraged.
UR - http://www.scopus.com/inward/record.url?scp=85057052016&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85057052016&partnerID=8YFLogxK
U2 - 10.1186/s12575-018-0087-4
DO - 10.1186/s12575-018-0087-4
M3 - Review article
AN - SCOPUS:85057052016
VL - 20
JO - Biological Procedures Online
JF - Biological Procedures Online
SN - 1480-9222
IS - 1
M1 - 22
ER -