Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice

Giuseppe Danilo Norata, Patrizia Marchesi, Silvia Passamonti, Angela Pirillo, Francesco Violi, Alberico Luigi Catapano

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

A strong negative correlation between polyphenols consumption and coronary heart disease has been extensively documented. These results prompted investigations on the mechanisms responsible for polyphenols effects in cardiovascular disease. The aim of this work was to investigate in apoE KO mice the effect of P183/1 (a mixture of cathechin, caffeic acid and resveratrol) on atherosclerosis and gene expression patterns in the vascular wall. ApoE KO mice were fed a diet supplemented with P183/1, 40 and 160 mg/kg body weight/day for 8 weeks. The supplementation with the high dose of P183/1 significantly reduced the presence of atherosclerotic plaque by 40 and 36% in the aortic sinus and in the ascending aorta, respectively. This reduction was associated with a reduced expression of markers for macrophages, lymphocytes (both Th1 and Th2) and of MCP-1, MIP-1α, MIP-1β, CCR1, CCR2 and ET1 in the vascular wall. In conclusion, P183/1 supplementation significantly decreases atherosclerosis in ApoE KO mice by affecting inflammatory cells recruitment and expression of pro-inflammatory chemokines in the vascular wall.

Original languageEnglish
Pages (from-to)265-271
Number of pages7
JournalAtherosclerosis
Volume191
Issue number2
DOIs
Publication statusPublished - Apr 2007

Fingerprint

Apolipoproteins E
Anti-Inflammatory Agents
Blood Vessels
Polyphenols
Atherosclerosis
Sinus of Valsalva
Atherosclerotic Plaques
Chemokines
Coronary Disease
Aorta
Cardiovascular Diseases
Macrophages
Body Weight
Lymphocytes
Diet
Gene Expression
resveratrol
caffeic acid
P183-1

Keywords

  • Chemokines
  • Inflammation
  • Polyphenols

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice. / Norata, Giuseppe Danilo; Marchesi, Patrizia; Passamonti, Silvia; Pirillo, Angela; Violi, Francesco; Catapano, Alberico Luigi.

In: Atherosclerosis, Vol. 191, No. 2, 04.2007, p. 265-271.

Research output: Contribution to journalArticle

Norata, Giuseppe Danilo ; Marchesi, Patrizia ; Passamonti, Silvia ; Pirillo, Angela ; Violi, Francesco ; Catapano, Alberico Luigi. / Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice. In: Atherosclerosis. 2007 ; Vol. 191, No. 2. pp. 265-271.
@article{4ef81fd9c333479da607011797d40e02,
title = "Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice",
abstract = "A strong negative correlation between polyphenols consumption and coronary heart disease has been extensively documented. These results prompted investigations on the mechanisms responsible for polyphenols effects in cardiovascular disease. The aim of this work was to investigate in apoE KO mice the effect of P183/1 (a mixture of cathechin, caffeic acid and resveratrol) on atherosclerosis and gene expression patterns in the vascular wall. ApoE KO mice were fed a diet supplemented with P183/1, 40 and 160 mg/kg body weight/day for 8 weeks. The supplementation with the high dose of P183/1 significantly reduced the presence of atherosclerotic plaque by 40 and 36{\%} in the aortic sinus and in the ascending aorta, respectively. This reduction was associated with a reduced expression of markers for macrophages, lymphocytes (both Th1 and Th2) and of MCP-1, MIP-1α, MIP-1β, CCR1, CCR2 and ET1 in the vascular wall. In conclusion, P183/1 supplementation significantly decreases atherosclerosis in ApoE KO mice by affecting inflammatory cells recruitment and expression of pro-inflammatory chemokines in the vascular wall.",
keywords = "Chemokines, Inflammation, Polyphenols",
author = "Norata, {Giuseppe Danilo} and Patrizia Marchesi and Silvia Passamonti and Angela Pirillo and Francesco Violi and Catapano, {Alberico Luigi}",
year = "2007",
month = "4",
doi = "10.1016/j.atherosclerosis.2006.05.047",
language = "English",
volume = "191",
pages = "265--271",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice

AU - Norata, Giuseppe Danilo

AU - Marchesi, Patrizia

AU - Passamonti, Silvia

AU - Pirillo, Angela

AU - Violi, Francesco

AU - Catapano, Alberico Luigi

PY - 2007/4

Y1 - 2007/4

N2 - A strong negative correlation between polyphenols consumption and coronary heart disease has been extensively documented. These results prompted investigations on the mechanisms responsible for polyphenols effects in cardiovascular disease. The aim of this work was to investigate in apoE KO mice the effect of P183/1 (a mixture of cathechin, caffeic acid and resveratrol) on atherosclerosis and gene expression patterns in the vascular wall. ApoE KO mice were fed a diet supplemented with P183/1, 40 and 160 mg/kg body weight/day for 8 weeks. The supplementation with the high dose of P183/1 significantly reduced the presence of atherosclerotic plaque by 40 and 36% in the aortic sinus and in the ascending aorta, respectively. This reduction was associated with a reduced expression of markers for macrophages, lymphocytes (both Th1 and Th2) and of MCP-1, MIP-1α, MIP-1β, CCR1, CCR2 and ET1 in the vascular wall. In conclusion, P183/1 supplementation significantly decreases atherosclerosis in ApoE KO mice by affecting inflammatory cells recruitment and expression of pro-inflammatory chemokines in the vascular wall.

AB - A strong negative correlation between polyphenols consumption and coronary heart disease has been extensively documented. These results prompted investigations on the mechanisms responsible for polyphenols effects in cardiovascular disease. The aim of this work was to investigate in apoE KO mice the effect of P183/1 (a mixture of cathechin, caffeic acid and resveratrol) on atherosclerosis and gene expression patterns in the vascular wall. ApoE KO mice were fed a diet supplemented with P183/1, 40 and 160 mg/kg body weight/day for 8 weeks. The supplementation with the high dose of P183/1 significantly reduced the presence of atherosclerotic plaque by 40 and 36% in the aortic sinus and in the ascending aorta, respectively. This reduction was associated with a reduced expression of markers for macrophages, lymphocytes (both Th1 and Th2) and of MCP-1, MIP-1α, MIP-1β, CCR1, CCR2 and ET1 in the vascular wall. In conclusion, P183/1 supplementation significantly decreases atherosclerosis in ApoE KO mice by affecting inflammatory cells recruitment and expression of pro-inflammatory chemokines in the vascular wall.

KW - Chemokines

KW - Inflammation

KW - Polyphenols

UR - http://www.scopus.com/inward/record.url?scp=33947188634&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947188634&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2006.05.047

DO - 10.1016/j.atherosclerosis.2006.05.047

M3 - Article

C2 - 16806235

AN - SCOPUS:33947188634

VL - 191

SP - 265

EP - 271

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -