Anti-inflammatory strategies to enhance islet engraftment and survival

Antonio Citro, Elisa Cantarelli, Lorenzo Piemonti

Research output: Contribution to journalArticle

Abstract

Early innate inflammatory reaction strongly affects islet engraftment and survival after intrahepatic transplantation. This early immune response is triggered by ischemia-reperfusion injury and instant blood mediated inflammatory reaction (IBMIR) occurring hours and days after islet infusion. Evidence in both mouse model and in human counterpart suggest the involvement of coagulation, complement system, and proinflammatory chemokines/cytokines. Identification and targeting of pathway(s), playing a role as "master regulator(s)" in post-transplant detrimental inflammatory events, is now mandatory to improve islet transplantation success. This review will focus on inflammatory pathway(s) differentially modulated by islet isolation and mainly associated with the early post-transplant events. Moreover, we will take into account anti-inflammatory strategies that have been tested at 2 levels: on the graft, ex vivo, during islet culture (i.e., donor) and/or on the graft site, in vivo, early after islet infusion (i.e., recipient).

Original languageEnglish
Pages (from-to)733-744
Number of pages12
JournalCurrent Diabetes Reports
Volume13
Issue number5
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Anti-inflammatory strategies
  • Chemokines
  • Danger signals
  • Early innate immune events
  • Instant blood mediated inflammatory reaction
  • Islet engraftment
  • Islet transplantation
  • Polymorphonuclear cells
  • Survival

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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