Anti-invasive effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), A natural inhibitor of metallo and serine proteases

Roberto Benelli, Roberta Venè, Davide Bisacchi, Spiridione Garbisa, Adriana Albini

Research output: Contribution to journalArticle

Abstract

Several reports have attributed to green tea chemopreventive and therapeutic properties. Epidemiological studies have linked the regular use of green tea to a reduced incidence of breast and colon carcinomas. Tea contains several antioxidants, including polyphenols of the catechin (green tea) and theaflavin (black tea) groups. Green tea derivatives have been shown to act in vitro and in vivo as anti-inflammatory, anti-viral and anti-tumor drugs. Despite the extensive body of data only few studies have investigated the molecular mechanisms underlying these effects. In this brief review we focus on the inhibitory activity of catechins derived from green tea toward proteases involved in tumor invasion.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalBiological Chemistry
Volume383
Issue number1
DOIs
Publication statusPublished - 2002

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Keywords

  • Antioxidant response elements (ARE)
  • Flavonoids
  • Metalloproteinase (MMP)
  • Tumor invasion
  • Urokinase (uPa)

ASJC Scopus subject areas

  • Biochemistry

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