Anti-Müllerian hormone concentrations and antral follicle counts for the prediction of pregnancy outcomes after intrauterine insemination

Francesca Moro, Anna Tropea, Elisa Scarinci, Emanuele Leoncini, Stefania Boccia, Alex Federico, Ornella Alesiani, Antonio Lanzone, Rosanna Apa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: To evaluate anti-Müllerian hormone (AMH) concentrations and antral follicle counts (AFCs) in the prediction of pregnancy outcomes after controlled ovarian stimulation among women undergoing intrauterine insemination. Methods: A retrospective study included women with unexplained infertility aged 41. years or younger who attended a fertility clinic in Italy between December 2009 and May 2014. Ovarian stimulation was achieved with recombinant follicle-stimulating hormone or highly purified human menopausal gonadotropin. Receiver operating characteristic curves were generated to predict ongoing pregnancy. The primary outcome was the association between AMH/AFC and ongoing pregnancy, and was assessed by logistic regression. Results: Overall, 276 women were included, of whom 43 (15.6%) achieved ongoing pregnancy. Multivariate analysis showed that women with a serum day-3 concentration of AMH higher than 2.3. ng/mL were more likely to have ongoing pregnancy than were those with a concentration lower than 2.3. ng/mL (odds ratio 5.84, 95% confidence interval 2.38-14.31; P

Original languageEnglish
JournalInternational Journal of Gynecology and Obstetrics
DOIs
Publication statusAccepted/In press - Apr 14 2015

Fingerprint

Insemination
Pregnancy Outcome
Hormones
Pregnancy
Ovulation Induction
Menotropins
Follicle Stimulating Hormone
ROC Curve
Infertility
Italy
Fertility
Multivariate Analysis
Retrospective Studies
Logistic Models
Odds Ratio
Confidence Intervals
Antral
Serum

Keywords

  • Anti-Müllerian hormone
  • Antral follicle count
  • Intrauterine insemination
  • Ovulation induction
  • Prediction

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Anti-Müllerian hormone concentrations and antral follicle counts for the prediction of pregnancy outcomes after intrauterine insemination. / Moro, Francesca; Tropea, Anna; Scarinci, Elisa; Leoncini, Emanuele; Boccia, Stefania; Federico, Alex; Alesiani, Ornella; Lanzone, Antonio; Apa, Rosanna.

In: International Journal of Gynecology and Obstetrics, 14.04.2015.

Research output: Contribution to journalArticle

Moro, Francesca ; Tropea, Anna ; Scarinci, Elisa ; Leoncini, Emanuele ; Boccia, Stefania ; Federico, Alex ; Alesiani, Ornella ; Lanzone, Antonio ; Apa, Rosanna. / Anti-Müllerian hormone concentrations and antral follicle counts for the prediction of pregnancy outcomes after intrauterine insemination. In: International Journal of Gynecology and Obstetrics. 2015.
@article{12069cc76c774905a845d958a6900560,
title = "Anti-M{\"u}llerian hormone concentrations and antral follicle counts for the prediction of pregnancy outcomes after intrauterine insemination",
abstract = "Objective: To evaluate anti-M{\"u}llerian hormone (AMH) concentrations and antral follicle counts (AFCs) in the prediction of pregnancy outcomes after controlled ovarian stimulation among women undergoing intrauterine insemination. Methods: A retrospective study included women with unexplained infertility aged 41. years or younger who attended a fertility clinic in Italy between December 2009 and May 2014. Ovarian stimulation was achieved with recombinant follicle-stimulating hormone or highly purified human menopausal gonadotropin. Receiver operating characteristic curves were generated to predict ongoing pregnancy. The primary outcome was the association between AMH/AFC and ongoing pregnancy, and was assessed by logistic regression. Results: Overall, 276 women were included, of whom 43 (15.6{\%}) achieved ongoing pregnancy. Multivariate analysis showed that women with a serum day-3 concentration of AMH higher than 2.3. ng/mL were more likely to have ongoing pregnancy than were those with a concentration lower than 2.3. ng/mL (odds ratio 5.84, 95{\%} confidence interval 2.38-14.31; P",
keywords = "Anti-M{\"u}llerian hormone, Antral follicle count, Intrauterine insemination, Ovulation induction, Prediction",
author = "Francesca Moro and Anna Tropea and Elisa Scarinci and Emanuele Leoncini and Stefania Boccia and Alex Federico and Ornella Alesiani and Antonio Lanzone and Rosanna Apa",
year = "2015",
month = "4",
day = "14",
doi = "10.1016/j.ijgo.2015.08.021",
language = "English",
journal = "International Journal of Gynecology and Obstetrics",
issn = "0020-7292",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Anti-Müllerian hormone concentrations and antral follicle counts for the prediction of pregnancy outcomes after intrauterine insemination

AU - Moro, Francesca

AU - Tropea, Anna

AU - Scarinci, Elisa

AU - Leoncini, Emanuele

AU - Boccia, Stefania

AU - Federico, Alex

AU - Alesiani, Ornella

AU - Lanzone, Antonio

AU - Apa, Rosanna

PY - 2015/4/14

Y1 - 2015/4/14

N2 - Objective: To evaluate anti-Müllerian hormone (AMH) concentrations and antral follicle counts (AFCs) in the prediction of pregnancy outcomes after controlled ovarian stimulation among women undergoing intrauterine insemination. Methods: A retrospective study included women with unexplained infertility aged 41. years or younger who attended a fertility clinic in Italy between December 2009 and May 2014. Ovarian stimulation was achieved with recombinant follicle-stimulating hormone or highly purified human menopausal gonadotropin. Receiver operating characteristic curves were generated to predict ongoing pregnancy. The primary outcome was the association between AMH/AFC and ongoing pregnancy, and was assessed by logistic regression. Results: Overall, 276 women were included, of whom 43 (15.6%) achieved ongoing pregnancy. Multivariate analysis showed that women with a serum day-3 concentration of AMH higher than 2.3. ng/mL were more likely to have ongoing pregnancy than were those with a concentration lower than 2.3. ng/mL (odds ratio 5.84, 95% confidence interval 2.38-14.31; P

AB - Objective: To evaluate anti-Müllerian hormone (AMH) concentrations and antral follicle counts (AFCs) in the prediction of pregnancy outcomes after controlled ovarian stimulation among women undergoing intrauterine insemination. Methods: A retrospective study included women with unexplained infertility aged 41. years or younger who attended a fertility clinic in Italy between December 2009 and May 2014. Ovarian stimulation was achieved with recombinant follicle-stimulating hormone or highly purified human menopausal gonadotropin. Receiver operating characteristic curves were generated to predict ongoing pregnancy. The primary outcome was the association between AMH/AFC and ongoing pregnancy, and was assessed by logistic regression. Results: Overall, 276 women were included, of whom 43 (15.6%) achieved ongoing pregnancy. Multivariate analysis showed that women with a serum day-3 concentration of AMH higher than 2.3. ng/mL were more likely to have ongoing pregnancy than were those with a concentration lower than 2.3. ng/mL (odds ratio 5.84, 95% confidence interval 2.38-14.31; P

KW - Anti-Müllerian hormone

KW - Antral follicle count

KW - Intrauterine insemination

KW - Ovulation induction

KW - Prediction

UR - http://www.scopus.com/inward/record.url?scp=84957927209&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957927209&partnerID=8YFLogxK

U2 - 10.1016/j.ijgo.2015.08.021

DO - 10.1016/j.ijgo.2015.08.021

M3 - Article

AN - SCOPUS:84957927209

JO - International Journal of Gynecology and Obstetrics

JF - International Journal of Gynecology and Obstetrics

SN - 0020-7292

ER -