Anti-MAG and anti-SGPG antibodies in neuropathy

Leonard H. Van Den Berg, Arthur P. Hays, Eduardo Nobile-Orazio, Lawrence J. Kinsella, Emanuela Manfredini, Massimo Corbo, Gorazd Rosoklija, David S. Younger, Robert E. Lovelace, Werner Trojaborg, Dale E. Lange, Steven Goldstein, Joel S. Delfiner, Saud A. Sadiq, William H. Sherman, Norman Latov

Research output: Contribution to journalArticle

Abstract

We compared the binding of human antibodies from patients with neuropathy to the myelin-associated glycoprotein (MAG), to its cross-reactive glycolipid sulfoglucuronyl paragloboside (SGPG), and to sections of peripheral nerve. Titers were correlated with the clinical presentation and results of electrophysiological and pathological studies. Most patients had a predominantly sensory or sensorimotor demyelinating neuropathy and highly elevated antibodies to both MAG and SGPG, but 2 had highly elevated antibodies to MAG alone, and 1 to SGPG alone. Two patients had predominantly motor neuropathy and highly elevated antibodies to SGPG which reacted with MAG by Western blot but not by enzyme-linked immunosorbent assay. One patient had amyotrophic lateral sclerosis and antibodies to SGPG but not to MAG. These studies indicate that the neuropathic syndrome associated with anti- MAG or -SGPG antibodies are more heterogeneous than previously suspected, and that although most of the antibodies react with both MAG and SGPG, some may react with MAG or SGPG alone.

Original languageEnglish
Pages (from-to)637-643
Number of pages7
JournalMuscle and Nerve
Volume19
Issue number5
DOIs
Publication statusPublished - May 1996

Keywords

  • autoantibodies
  • autoimmune disease
  • myelin-associated glycoprotein (MAG)
  • peripheral neuropathy
  • sulfoglucuronyl paragloboside (SGPG)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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  • Cite this

    Van Den Berg, L. H., Hays, A. P., Nobile-Orazio, E., Kinsella, L. J., Manfredini, E., Corbo, M., Rosoklija, G., Younger, D. S., Lovelace, R. E., Trojaborg, W., Lange, D. E., Goldstein, S., Delfiner, J. S., Sadiq, S. A., Sherman, W. H., & Latov, N. (1996). Anti-MAG and anti-SGPG antibodies in neuropathy. Muscle and Nerve, 19(5), 637-643. https://doi.org/10.1002/(SICI)1097-4598(199605)19:5<637::AID-MUS12>3.0.CO;2-K