Anti-MAG IgM antibodies in patients with neuropathy and IgM M proteins: Detection by ELISA

Eduardo Nobile-Orazio, Tom Vietorisz, Mary Jo Messito, William H. Sherman, Norman Latov

Research output: Contribution to journalArticlepeer-review

Abstract

In some patients with plasma cell dyscrasia and neuropathy, there are IgM M proteins that react with the myelin-associated glycoprotein (MAG). We used an enzyme-linked immunosorbent assay (ELISA) system to detect anti-MAG IgM antibodies. Reactivity with human MAG by ELISA correlated with demonstration of anti-MAG IgM antibodies by the “immunoblot” technique. Human MAG was more effective than bovine MAG as antigen, and there was no significant reactivity with mouse MAG. The ELISA system is a simple and convenient method for detecting anti-MAG IgM antibodies.

Original languageEnglish
Pages (from-to)939-942
Number of pages4
JournalNeurology
Volume33
Issue number7
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

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