Anti-mitochondrial type M5 and anti-cardiolipin antibodies in autoimmune disorders: Studies on their association and cross-reactivity

P. L. Meroni, E. N. Harris, A. Brucato, A. Tincani, W. Barcellini, A. Vismara, G. Balestrieri, G. R. Hughes, C. Zanussi

Research output: Contribution to journalArticlepeer-review

Abstract

In a series of 42 positive sera, anti-mitochondrial type M5 antibodies (AMA-M5) were found most frequently in patients with SLE (24) and SLE-like syndromes (10). Patients with AMA-M5 displayed a higher prevalence of thrombocytopenia, thrombosis, biological false positive seroreactions for syphilis, lupus-like anticoagulant activity and anti-cardiolipin antibodies in comparison with a group of 43 SLE AMA-M5 negative patients. The strong association between anti-phospholipid and AMA-M5 antibodies cannot be explained entirely by cross-reactivity between these two groups of antibodies, as indicated by absorption experiments and studies using affinity purified antibody preparations. However, cardiolipin liposomes were able to reduce partially the titres of AMA-M5 sera, suggesting that a small population of AMA-M5 antibodies exists that cross-reacts with cardiolipin. The existence of this population was further substantiated by our demonstration that an IgM monoclonal antibody, from a patient with Waldenstrom's macroglobulinaemia, displayed both anti-cardiolipin and AMA-M5 activity, and AMA-M5 activity was completely inhibited by cardiolipin.

Original languageEnglish
Pages (from-to)484-491
Number of pages8
JournalClinical and Experimental Immunology
Volume67
Issue number3
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Immunology

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