Anti-myelin antibodies predict the clinical outcome after a first episode suggestive of MS

V. Tomassini; L. De Giglio; M. Reindl; P. Russo; I. Pestalozza; P. Pantano; T. Berger; Carlo Pozzilli

doi:10.1177/1352458507077622

Anti-myelin antibodies predict the clinical outcome after a first episode suggestive of MS

V. Tomassini, L. De Giglio, M. Reindl, P. Russo, I. Pestalozza, P. Pantano, T. Berger, Carlo Pozzilli

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this study was to test the contribution of anti-myelin antibodies in predicting conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) when considering either Poser's or McDonald's diagnostic criteria. Fifty-one patients with CIS and abnormal brain MRI were imaged monthly for six months and then at 12, 18, 24, 36 months. At baseline serum samples testing antibodies against myelin oligodendrocyte glycoprotein (anti-MOG) and myelin basic protein (anti-MBP) were collected. During the 36-month follow-up, 26 (51%) patients developed a relapse thus becoming clinically definite MS (CDMS) according to Poser's criteria; 46 (90.2%) patients converted to MS according to McDonald's criteria. Out of 51 patients, 28 (54.9%) had either double or single positivity for anti-myelin antibodies. Antibody status significantly predicted MS according to Poser's criteria (P=0.004), but did not according to the McDonald's criteria. When compared to antibody negative patients, the risk of developing a relapse was 8.9 (95% Cl: 2.7-29.8; P

Original language	English
Pages (from-to)	1086-1094
Number of pages	9
Journal	Multiple Sclerosis Journal
Volume	13
Issue number	9
DOIs	https://doi.org/10.1177/1352458507077622
Publication status	Published - Nov 2007

Keywords

Clinically isolated syndrome
MBP antibodies
MOG antibodies
MRI
Multiple sclerosis
Relapse

ASJC Scopus subject areas

Clinical Neurology

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10.1177/1352458507077622

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title = "Anti-myelin antibodies predict the clinical outcome after a first episode suggestive of MS",

abstract = "The aim of this study was to test the contribution of anti-myelin antibodies in predicting conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) when considering either Poser's or McDonald's diagnostic criteria. Fifty-one patients with CIS and abnormal brain MRI were imaged monthly for six months and then at 12, 18, 24, 36 months. At baseline serum samples testing antibodies against myelin oligodendrocyte glycoprotein (anti-MOG) and myelin basic protein (anti-MBP) were collected. During the 36-month follow-up, 26 (51%) patients developed a relapse thus becoming clinically definite MS (CDMS) according to Poser's criteria; 46 (90.2%) patients converted to MS according to McDonald's criteria. Out of 51 patients, 28 (54.9%) had either double or single positivity for anti-myelin antibodies. Antibody status significantly predicted MS according to Poser's criteria (P=0.004), but did not according to the McDonald's criteria. When compared to antibody negative patients, the risk of developing a relapse was 8.9 (95% Cl: 2.7-29.8; P",

keywords = "Clinically isolated syndrome, MBP antibodies, MOG antibodies, MRI, Multiple sclerosis, Relapse",

author = "V. Tomassini and {De Giglio}, L. and M. Reindl and P. Russo and I. Pestalozza and P. Pantano and T. Berger and Carlo Pozzilli",

year = "2007",

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doi = "10.1177/1352458507077622",

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AU - Tomassini, V.

AU - De Giglio, L.

AU - Reindl, M.

AU - Russo, P.

AU - Pestalozza, I.

AU - Pantano, P.

AU - Berger, T.

AU - Pozzilli, Carlo

PY - 2007/11

Y1 - 2007/11

N2 - The aim of this study was to test the contribution of anti-myelin antibodies in predicting conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) when considering either Poser's or McDonald's diagnostic criteria. Fifty-one patients with CIS and abnormal brain MRI were imaged monthly for six months and then at 12, 18, 24, 36 months. At baseline serum samples testing antibodies against myelin oligodendrocyte glycoprotein (anti-MOG) and myelin basic protein (anti-MBP) were collected. During the 36-month follow-up, 26 (51%) patients developed a relapse thus becoming clinically definite MS (CDMS) according to Poser's criteria; 46 (90.2%) patients converted to MS according to McDonald's criteria. Out of 51 patients, 28 (54.9%) had either double or single positivity for anti-myelin antibodies. Antibody status significantly predicted MS according to Poser's criteria (P=0.004), but did not according to the McDonald's criteria. When compared to antibody negative patients, the risk of developing a relapse was 8.9 (95% Cl: 2.7-29.8; P

AB - The aim of this study was to test the contribution of anti-myelin antibodies in predicting conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) when considering either Poser's or McDonald's diagnostic criteria. Fifty-one patients with CIS and abnormal brain MRI were imaged monthly for six months and then at 12, 18, 24, 36 months. At baseline serum samples testing antibodies against myelin oligodendrocyte glycoprotein (anti-MOG) and myelin basic protein (anti-MBP) were collected. During the 36-month follow-up, 26 (51%) patients developed a relapse thus becoming clinically definite MS (CDMS) according to Poser's criteria; 46 (90.2%) patients converted to MS according to McDonald's criteria. Out of 51 patients, 28 (54.9%) had either double or single positivity for anti-myelin antibodies. Antibody status significantly predicted MS according to Poser's criteria (P=0.004), but did not according to the McDonald's criteria. When compared to antibody negative patients, the risk of developing a relapse was 8.9 (95% Cl: 2.7-29.8; P

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KW - Multiple sclerosis

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Anti-myelin antibodies predict the clinical outcome after a first episode suggestive of MS

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