Anti-neuronal nicotinic receptor antibodies in MG patients with thymoma

Cecilia Gotti, Milena Moretti, Renato Mantegazza, Diego Fornasari, Theodore Tsouloufis, Francesco Clementi

Research output: Contribution to journalArticle

Abstract

We tested 24 MG patients with thymoma (11 invasive) for the presence of anti-neuronal nicotinic receptor subtype antibodies and found that none had antibodies against the α7-containing subtype, and only one (with invasive thymoma) had antibodies directed against the α3-containing subtype. In this patient, the anti-α3 antibodies recognized the extracellular part of the α3 subunit. They developed later than the anti-α1 muscle antibodies, with their titer increasing during the illness, while that of the anti-α1 muscle antibody decreased. Our data suggest that there is no correlation between the presence of anti-α3 antibodies and thymoma.

Original languageEnglish
Pages (from-to)142-145
Number of pages4
JournalJournal of Neuroimmunology
Volume113
Issue number1
DOIs
Publication statusPublished - Feb 1 2001

Keywords

  • Antibodies
  • Myasthenia gravis
  • Neuronal nicotinic receptor subtypes
  • Thymoma

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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