We tested 24 MG patients with thymoma (11 invasive) for the presence of anti-neuronal nicotinic receptor subtype antibodies and found that none had antibodies against the α7-containing subtype, and only one (with invasive thymoma) had antibodies directed against the α3-containing subtype. In this patient, the anti-α3 antibodies recognized the extracellular part of the α3 subunit. They developed later than the anti-α1 muscle antibodies, with their titer increasing during the illness, while that of the anti-α1 muscle antibody decreased. Our data suggest that there is no correlation between the presence of anti-α3 antibodies and thymoma.
- Myasthenia gravis
- Neuronal nicotinic receptor subtypes
ASJC Scopus subject areas
- Immunology and Allergy
- Clinical Neurology