Anticorpi anticitoplasma dei neutrofili (ANCA)

Translated title of the contribution: Anti-neutrophil cytoplasmic antibodies (ANCA)

Research output: Contribution to journalArticle

Abstract

Antineutrophil cytoplasmic antibodies (ANCA) are specific antibodies for antigens in cytoplasmic granules of neutrophils and monocyte lysosomes, first reported in 1982. These antibodies can be detected with indirect immunofluorescence microscopy. Two major patterns of staining are present: cytoplasmic ANCA (c-ANCA) and perinuclear ANCA (p-ANCA). Specific immunochemical assays demonstrate that c-ANCA are mainly antibodies to proteinase 3, and p-ANCA are antibodies to myeloperoxidase. ANCA are important serological markers for the primary systemic small-vessel vasculitis including microscopic polyangiitis, Wegener granulomatosis, Churg Strauss syndrome, and drug induced vasculitis. Numerous reports have established the clinical utility of ANCA titers in monitoring disease activity, relapses, and response to treatment. The c-ANCA pattern is highly specific for Wegener's granulomatosis; p-ANCA is found in sera of individual patients with microscopic polyangiitis and Churg Strauss syndrome. A rapid diagnosis of ANCA small-vessel vasculitis is critically important, because life-threatening injury to organs often develops quickly and is mitigated dramatically by immunosuppressive therapy.

Original languageItalian
Pages (from-to)364-372
Number of pages9
JournalProgressi in Reumatologia
Volume5
Issue number4
Publication statusPublished - 2004

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Antineutrophil Cytoplasmic Antibodies
Vasculitis
Microscopic Polyangiitis
Churg-Strauss Syndrome
Granulomatosis with Polyangiitis
Antibodies
Myeloblastin
Cytoplasmic Granules
Immunosuppressive Agents
Indirect Fluorescent Antibody Technique
Lysosomes
Fluorescence Microscopy
Peroxidase
Monocytes
Neutrophils
Staining and Labeling
Antigens
Recurrence

ASJC Scopus subject areas

  • Rheumatology

Cite this

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title = "Anticorpi anticitoplasma dei neutrofili (ANCA)",
abstract = "Antineutrophil cytoplasmic antibodies (ANCA) are specific antibodies for antigens in cytoplasmic granules of neutrophils and monocyte lysosomes, first reported in 1982. These antibodies can be detected with indirect immunofluorescence microscopy. Two major patterns of staining are present: cytoplasmic ANCA (c-ANCA) and perinuclear ANCA (p-ANCA). Specific immunochemical assays demonstrate that c-ANCA are mainly antibodies to proteinase 3, and p-ANCA are antibodies to myeloperoxidase. ANCA are important serological markers for the primary systemic small-vessel vasculitis including microscopic polyangiitis, Wegener granulomatosis, Churg Strauss syndrome, and drug induced vasculitis. Numerous reports have established the clinical utility of ANCA titers in monitoring disease activity, relapses, and response to treatment. The c-ANCA pattern is highly specific for Wegener's granulomatosis; p-ANCA is found in sera of individual patients with microscopic polyangiitis and Churg Strauss syndrome. A rapid diagnosis of ANCA small-vessel vasculitis is critically important, because life-threatening injury to organs often develops quickly and is mitigated dramatically by immunosuppressive therapy.",
keywords = "ANCA, ANCA-associated vasculitis, Myeloperoxidase, Proteinase-3",
author = "S. Rossi and Roberto Caporali and L. Cavagna and S. Bugatti and C. Montecucco",
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language = "Italian",
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T1 - Anticorpi anticitoplasma dei neutrofili (ANCA)

AU - Rossi, S.

AU - Caporali, Roberto

AU - Cavagna, L.

AU - Bugatti, S.

AU - Montecucco, C.

PY - 2004

Y1 - 2004

N2 - Antineutrophil cytoplasmic antibodies (ANCA) are specific antibodies for antigens in cytoplasmic granules of neutrophils and monocyte lysosomes, first reported in 1982. These antibodies can be detected with indirect immunofluorescence microscopy. Two major patterns of staining are present: cytoplasmic ANCA (c-ANCA) and perinuclear ANCA (p-ANCA). Specific immunochemical assays demonstrate that c-ANCA are mainly antibodies to proteinase 3, and p-ANCA are antibodies to myeloperoxidase. ANCA are important serological markers for the primary systemic small-vessel vasculitis including microscopic polyangiitis, Wegener granulomatosis, Churg Strauss syndrome, and drug induced vasculitis. Numerous reports have established the clinical utility of ANCA titers in monitoring disease activity, relapses, and response to treatment. The c-ANCA pattern is highly specific for Wegener's granulomatosis; p-ANCA is found in sera of individual patients with microscopic polyangiitis and Churg Strauss syndrome. A rapid diagnosis of ANCA small-vessel vasculitis is critically important, because life-threatening injury to organs often develops quickly and is mitigated dramatically by immunosuppressive therapy.

AB - Antineutrophil cytoplasmic antibodies (ANCA) are specific antibodies for antigens in cytoplasmic granules of neutrophils and monocyte lysosomes, first reported in 1982. These antibodies can be detected with indirect immunofluorescence microscopy. Two major patterns of staining are present: cytoplasmic ANCA (c-ANCA) and perinuclear ANCA (p-ANCA). Specific immunochemical assays demonstrate that c-ANCA are mainly antibodies to proteinase 3, and p-ANCA are antibodies to myeloperoxidase. ANCA are important serological markers for the primary systemic small-vessel vasculitis including microscopic polyangiitis, Wegener granulomatosis, Churg Strauss syndrome, and drug induced vasculitis. Numerous reports have established the clinical utility of ANCA titers in monitoring disease activity, relapses, and response to treatment. The c-ANCA pattern is highly specific for Wegener's granulomatosis; p-ANCA is found in sera of individual patients with microscopic polyangiitis and Churg Strauss syndrome. A rapid diagnosis of ANCA small-vessel vasculitis is critically important, because life-threatening injury to organs often develops quickly and is mitigated dramatically by immunosuppressive therapy.

KW - ANCA

KW - ANCA-associated vasculitis

KW - Myeloperoxidase

KW - Proteinase-3

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