Anti-nuclear antibodies as predictor of outcome in a multi-center cohort of Italian children and adolescents with Raynaud’s phenomenon

Fernanda Falcini, Donato Rigante, Marcello Candelli, Giorgia Martini, Fabrizia Corona, Antonella Petaccia, Francesco La Torre, Carmela G L Raffaele, Marco Matucci Cerinic

Research output: Contribution to journalArticle

Abstract

A retrospective multi-center data collection of clinical, laboratory, and treatment characteristics of 94 Caucasian children and adolescents with Raynaud’s phenomenon (RP) started at a mean age of 12.8 ± 5 years, with variable involvement of hands, feet, and face, was performed for a period of 3 years. Collected data included nailfold videocapillaroscopy (NVC), lung function tests, and different laboratory tests finalized to characterize an eventual connective tissue disease (CTD), disclosed by RP itself. Twelve patients presented an early-scleroderma pattern at NVC, 1 a late-scleroderma pattern, and 58 a nonspecific pattern. Laboratory data results showed the positivity of anti-nuclear antibodies (ANA) in 29 % of patients. After this 3-year period of observation, 8 patients had developed a CTD. Our data examined by multivariate analysis, though limited to a multi-center cohort of pediatric patients with RP, strongly suggest that ANA positivity is a significant predictor of progression of RP towards a CTD.

Original languageEnglish
Pages (from-to)167-169
Number of pages3
JournalClinical Rheumatology
Volume34
Issue number1
DOIs
Publication statusPublished - 2015

Fingerprint

Raynaud Disease
Connective Tissue Diseases
Anti-Idiotypic Antibodies
Microscopic Angioscopy
Respiratory Function Tests
Foot
Multivariate Analysis
Hand
Observation
Pediatrics
Therapeutics

Keywords

  • Pediatric rheumatology
  • Raynaud’s syndrome
  • Rheumatic diseases
  • Specialty fields

ASJC Scopus subject areas

  • Rheumatology
  • Medicine(all)

Cite this

Anti-nuclear antibodies as predictor of outcome in a multi-center cohort of Italian children and adolescents with Raynaud’s phenomenon. / Falcini, Fernanda; Rigante, Donato; Candelli, Marcello; Martini, Giorgia; Corona, Fabrizia; Petaccia, Antonella; La Torre, Francesco; Raffaele, Carmela G L; Matucci Cerinic, Marco.

In: Clinical Rheumatology, Vol. 34, No. 1, 2015, p. 167-169.

Research output: Contribution to journalArticle

Falcini, F, Rigante, D, Candelli, M, Martini, G, Corona, F, Petaccia, A, La Torre, F, Raffaele, CGL & Matucci Cerinic, M 2015, 'Anti-nuclear antibodies as predictor of outcome in a multi-center cohort of Italian children and adolescents with Raynaud’s phenomenon', Clinical Rheumatology, vol. 34, no. 1, pp. 167-169. https://doi.org/10.1007/s10067-014-2833-6
Falcini, Fernanda ; Rigante, Donato ; Candelli, Marcello ; Martini, Giorgia ; Corona, Fabrizia ; Petaccia, Antonella ; La Torre, Francesco ; Raffaele, Carmela G L ; Matucci Cerinic, Marco. / Anti-nuclear antibodies as predictor of outcome in a multi-center cohort of Italian children and adolescents with Raynaud’s phenomenon. In: Clinical Rheumatology. 2015 ; Vol. 34, No. 1. pp. 167-169.
@article{336a0932e3604d41ace7a5d0b4206765,
title = "Anti-nuclear antibodies as predictor of outcome in a multi-center cohort of Italian children and adolescents with Raynaud’s phenomenon",
abstract = "A retrospective multi-center data collection of clinical, laboratory, and treatment characteristics of 94 Caucasian children and adolescents with Raynaud’s phenomenon (RP) started at a mean age of 12.8 ± 5 years, with variable involvement of hands, feet, and face, was performed for a period of 3 years. Collected data included nailfold videocapillaroscopy (NVC), lung function tests, and different laboratory tests finalized to characterize an eventual connective tissue disease (CTD), disclosed by RP itself. Twelve patients presented an early-scleroderma pattern at NVC, 1 a late-scleroderma pattern, and 58 a nonspecific pattern. Laboratory data results showed the positivity of anti-nuclear antibodies (ANA) in 29 {\%} of patients. After this 3-year period of observation, 8 patients had developed a CTD. Our data examined by multivariate analysis, though limited to a multi-center cohort of pediatric patients with RP, strongly suggest that ANA positivity is a significant predictor of progression of RP towards a CTD.",
keywords = "Pediatric rheumatology, Raynaud’s syndrome, Rheumatic diseases, Specialty fields",
author = "Fernanda Falcini and Donato Rigante and Marcello Candelli and Giorgia Martini and Fabrizia Corona and Antonella Petaccia and {La Torre}, Francesco and Raffaele, {Carmela G L} and {Matucci Cerinic}, Marco",
year = "2015",
doi = "10.1007/s10067-014-2833-6",
language = "English",
volume = "34",
pages = "167--169",
journal = "Clinical Rheumatology",
issn = "0770-3198",
publisher = "Springer London",
number = "1",

}

TY - JOUR

T1 - Anti-nuclear antibodies as predictor of outcome in a multi-center cohort of Italian children and adolescents with Raynaud’s phenomenon

AU - Falcini, Fernanda

AU - Rigante, Donato

AU - Candelli, Marcello

AU - Martini, Giorgia

AU - Corona, Fabrizia

AU - Petaccia, Antonella

AU - La Torre, Francesco

AU - Raffaele, Carmela G L

AU - Matucci Cerinic, Marco

PY - 2015

Y1 - 2015

N2 - A retrospective multi-center data collection of clinical, laboratory, and treatment characteristics of 94 Caucasian children and adolescents with Raynaud’s phenomenon (RP) started at a mean age of 12.8 ± 5 years, with variable involvement of hands, feet, and face, was performed for a period of 3 years. Collected data included nailfold videocapillaroscopy (NVC), lung function tests, and different laboratory tests finalized to characterize an eventual connective tissue disease (CTD), disclosed by RP itself. Twelve patients presented an early-scleroderma pattern at NVC, 1 a late-scleroderma pattern, and 58 a nonspecific pattern. Laboratory data results showed the positivity of anti-nuclear antibodies (ANA) in 29 % of patients. After this 3-year period of observation, 8 patients had developed a CTD. Our data examined by multivariate analysis, though limited to a multi-center cohort of pediatric patients with RP, strongly suggest that ANA positivity is a significant predictor of progression of RP towards a CTD.

AB - A retrospective multi-center data collection of clinical, laboratory, and treatment characteristics of 94 Caucasian children and adolescents with Raynaud’s phenomenon (RP) started at a mean age of 12.8 ± 5 years, with variable involvement of hands, feet, and face, was performed for a period of 3 years. Collected data included nailfold videocapillaroscopy (NVC), lung function tests, and different laboratory tests finalized to characterize an eventual connective tissue disease (CTD), disclosed by RP itself. Twelve patients presented an early-scleroderma pattern at NVC, 1 a late-scleroderma pattern, and 58 a nonspecific pattern. Laboratory data results showed the positivity of anti-nuclear antibodies (ANA) in 29 % of patients. After this 3-year period of observation, 8 patients had developed a CTD. Our data examined by multivariate analysis, though limited to a multi-center cohort of pediatric patients with RP, strongly suggest that ANA positivity is a significant predictor of progression of RP towards a CTD.

KW - Pediatric rheumatology

KW - Raynaud’s syndrome

KW - Rheumatic diseases

KW - Specialty fields

UR - http://www.scopus.com/inward/record.url?scp=84922104778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922104778&partnerID=8YFLogxK

U2 - 10.1007/s10067-014-2833-6

DO - 10.1007/s10067-014-2833-6

M3 - Article

C2 - 25428518

AN - SCOPUS:84922104778

VL - 34

SP - 167

EP - 169

JO - Clinical Rheumatology

JF - Clinical Rheumatology

SN - 0770-3198

IS - 1

ER -