Anti-PD-1 versus anti-PD-L1 therapy in patients with pretreated advanced non-small-cell lung cancer: A meta-analysis

Alfredo Tartarone, Giandomenico Roviello, Rosa Lerose, Raheleh Roudi, Michele Aieta, Pietro Zoppoli

Research output: Contribution to journalReview articlepeer-review

Abstract

Aim: At present three immune checkpoint inhibitors (ICIs), two anti-PD-1 (nivolumab and pembrolizumab) and one anti-PD-L1 (atezolizumab) can be used in pretreated non-small-cell lung cancer patients. The aim of this meta-analysis is an indirect comparison between anti-PD-1 and anti-PD-L1 inhibitors. Methods: Seven studies (>4000 patients) were considered. Results: Considering the overall survival ICIs showed very robust efficacy over docetaxel, while in terms of progression-free survival the therapy with ICIs is slightly favored. Anti-PD-1 gives a more significant benefit than anti-PD-L1; however, excluding the KEYNOTE 010 trial that enrolled only PD-L1-positive patients, the subgroup difference remains only in terms of progression-free survival. Conclusion: This meta-analysis confirms the superiority of ICIs over docetaxel in pretreated non-small-cell lung cancer patients and would indicate a slight benefit from anti-PD-1 than from anti-PD-L1 inhibitors, always keeping in mind the possible biases of this indirect comparison.

Original languageEnglish
Pages (from-to)2423-2433
Number of pages11
JournalFuture Oncology
Volume15
Issue number20
DOIs
Publication statusPublished - Jul 1 2019

Keywords

  • atezolizumab
  • avelumab
  • checkpoint inhibitors
  • immunotherapy
  • meta-analysis
  • nivolumab
  • non-small-cell lung cancer
  • pembrolizumab

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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