Anti-phospholipid antibodies and thrombotic thrombocytopenic purpura

C. Montecucco, M. Di Lauro, E. Bobbio-Pallavicini, M. Longhi, R. Caporali, F. De Gennaro, E. Ascari

Research output: Contribution to journalArticle

Abstract

Anti-phospholipid antibodies were measured in 9 patients with active thrombotic thrombocytopenic purpura (TTP). 8 patients had primary TTP and one had TTP secondary to systemic lupus erythematosus (SLE). No patient showed circulating 'lupus' anticoagulants or false positive tests for syphilis. A solid phase immuno-assay for anti-cardiolipin antibodies (ACA) gave negative results in the patients with secondary TTP as well as in all but one case with primary TTP. ACA of IgG class were not found in any TTP patient while they were present in 10 out of 18 patients suffering from thrombocytopenia with active SLE. These data indicate that anti-phospholipid antibodies do not have a role in the development of thrombosis and thrombocytopenia with TTP.

Original languageEnglish
Pages (from-to)355-358
Number of pages4
JournalClinical and Experimental Rheumatology
Volume5
Issue number4
Publication statusPublished - 1987

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Thrombotic Thrombocytopenic Purpura
Anti-Idiotypic Antibodies
Phospholipids
Cardiolipins
Thrombocytopenia
Systemic Lupus Erythematosus
Lupus Coagulation Inhibitor
Immunoglobulin Isotypes
Syphilis
Thrombosis
Immunoglobulin G

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Montecucco, C., Di Lauro, M., Bobbio-Pallavicini, E., Longhi, M., Caporali, R., De Gennaro, F., & Ascari, E. (1987). Anti-phospholipid antibodies and thrombotic thrombocytopenic purpura. Clinical and Experimental Rheumatology, 5(4), 355-358.

Anti-phospholipid antibodies and thrombotic thrombocytopenic purpura. / Montecucco, C.; Di Lauro, M.; Bobbio-Pallavicini, E.; Longhi, M.; Caporali, R.; De Gennaro, F.; Ascari, E.

In: Clinical and Experimental Rheumatology, Vol. 5, No. 4, 1987, p. 355-358.

Research output: Contribution to journalArticle

Montecucco, C, Di Lauro, M, Bobbio-Pallavicini, E, Longhi, M, Caporali, R, De Gennaro, F & Ascari, E 1987, 'Anti-phospholipid antibodies and thrombotic thrombocytopenic purpura', Clinical and Experimental Rheumatology, vol. 5, no. 4, pp. 355-358.
Montecucco C, Di Lauro M, Bobbio-Pallavicini E, Longhi M, Caporali R, De Gennaro F et al. Anti-phospholipid antibodies and thrombotic thrombocytopenic purpura. Clinical and Experimental Rheumatology. 1987;5(4):355-358.
Montecucco, C. ; Di Lauro, M. ; Bobbio-Pallavicini, E. ; Longhi, M. ; Caporali, R. ; De Gennaro, F. ; Ascari, E. / Anti-phospholipid antibodies and thrombotic thrombocytopenic purpura. In: Clinical and Experimental Rheumatology. 1987 ; Vol. 5, No. 4. pp. 355-358.
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