Anti-pituitary antibodies in children with newly diagnosed celiac disease: A novel finding contributing to linear-growth impairment

Maurizio Delvecchio, Annamaria De Bellis, Ruggiero Francavilla, Vincenzo Rutigliano, Barbara Predieri, Flavia Indrio, Domenica De Venuto, Antonio Agostino Sinisi, Antonio Bizzarro, Antonio Bellastella, Lorenzo Iughetti, Luciano Cavallo

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Abstract

Objectives: The possible autoimmune involvement of the pituitary gland in patients with celiac disease (CD) has been suggested but demonstrated in only a few patients on gluten-free diet. We aimed to assess the prevalence and clinical meaning of anti-pituitary antibodies (APA) in children and adolescents with the newly diagnosed CD.Methods: A total of 119 patients with CD (0.9-15.8 years old) attending the inpatient clinic of University Hospital were recruited for the cross-sectional study. Their height, weight, and body mass index (BMI) were recorded, and insulin-like growth factor-1 (IGF-1) and APA were assayed. APA was also determined in 98 sex-and age-matched controls.Results: APA were detected in 50 patients (42.0%), 15 of them with high titer (30%) and 35 with low titer (70%), and in 2 control subjects at low titer (2%) (P

Original languageEnglish
Pages (from-to)691-696
Number of pages6
JournalAmerican Journal of Gastroenterology
Volume105
Issue number3
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Gastroenterology

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    Delvecchio, M., De Bellis, A., Francavilla, R., Rutigliano, V., Predieri, B., Indrio, F., De Venuto, D., Sinisi, A. A., Bizzarro, A., Bellastella, A., Iughetti, L., & Cavallo, L. (2010). Anti-pituitary antibodies in children with newly diagnosed celiac disease: A novel finding contributing to linear-growth impairment. American Journal of Gastroenterology, 105(3), 691-696. https://doi.org/10.1038/ajg.2009.642