TY - JOUR
T1 - Anti-pituitary antibodies in children with newly diagnosed celiac disease
T2 - A novel finding contributing to linear-growth impairment
AU - Delvecchio, Maurizio
AU - De Bellis, Annamaria
AU - Francavilla, Ruggiero
AU - Rutigliano, Vincenzo
AU - Predieri, Barbara
AU - Indrio, Flavia
AU - De Venuto, Domenica
AU - Sinisi, Antonio Agostino
AU - Bizzarro, Antonio
AU - Bellastella, Antonio
AU - Iughetti, Lorenzo
AU - Cavallo, Luciano
PY - 2010
Y1 - 2010
N2 - Objectives: The possible autoimmune involvement of the pituitary gland in patients with celiac disease (CD) has been suggested but demonstrated in only a few patients on gluten-free diet. We aimed to assess the prevalence and clinical meaning of anti-pituitary antibodies (APA) in children and adolescents with the newly diagnosed CD.Methods: A total of 119 patients with CD (0.9-15.8 years old) attending the inpatient clinic of University Hospital were recruited for the cross-sectional study. Their height, weight, and body mass index (BMI) were recorded, and insulin-like growth factor-1 (IGF-1) and APA were assayed. APA was also determined in 98 sex-and age-matched controls.Results: APA were detected in 50 patients (42.0%), 15 of them with high titer (30%) and 35 with low titer (70%), and in 2 control subjects at low titer (2%) (P
AB - Objectives: The possible autoimmune involvement of the pituitary gland in patients with celiac disease (CD) has been suggested but demonstrated in only a few patients on gluten-free diet. We aimed to assess the prevalence and clinical meaning of anti-pituitary antibodies (APA) in children and adolescents with the newly diagnosed CD.Methods: A total of 119 patients with CD (0.9-15.8 years old) attending the inpatient clinic of University Hospital were recruited for the cross-sectional study. Their height, weight, and body mass index (BMI) were recorded, and insulin-like growth factor-1 (IGF-1) and APA were assayed. APA was also determined in 98 sex-and age-matched controls.Results: APA were detected in 50 patients (42.0%), 15 of them with high titer (30%) and 35 with low titer (70%), and in 2 control subjects at low titer (2%) (P
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U2 - 10.1038/ajg.2009.642
DO - 10.1038/ajg.2009.642
M3 - Article
C2 - 19904244
AN - SCOPUS:77949268977
VL - 105
SP - 691
EP - 696
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
SN - 0002-9270
IS - 3
ER -