Anti-polymer antibodies are correlated with pain and fatigue severity in patients with fibromyalgia syndrome

Piercarlo Sarzi-Puttini, Fabiola Atzeni, Manuela Di Franco, Nicola Lama, Alberto Batticciotto, Cristina Iannuccelli, Donata Dell'Acqua, Simona De Portu, Valeria Riccieri, Mario Carrabba, Dan Buskila, Andrea Doria, Guido Valesini

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: To investigate the prevalence of antipolymer antibody (APA) in patients with fibromyalgia (FM) and to examine its association with FM severity symptoms. Methods: The study population consisted of 79 FM patients and 75 controls: 32 with psoriatic arthritis and 43 with rheumatoid arthritis APA levels were indirectly assayed using a commercial ELISA kit from Corgenix (Westmister, Colorado, USA). Optical density (OD) values were recorded on duplicates of each of the reference and patient samples. Among clinical variables we investigated pain, measured according to visual analog scales (VAS: 0-100), fatigue, stiffness, anxiety, depression, all measured by VAS (0-100), and health status measured by Fibromyalgia Impact Questionnaire (FIQ). Results: Sixteen of the 79 FM patients (20.3%) and 12/78 controls (15.4%) were positive for APAs (P=0.536). Following ROC analysis, area under curve (AUC) was 0.49 (95% CI: 0.40, 0.58). Focusing on FM patients, we observed a correlation between APA titre and pain (τ: -0.221; P=0.020) and fatigue (τ: -0.205; P=0.032) at univariate analysis. Binomial regression analysis, controlling for clinical and demographic variables, showed that pain (PPR: 0.923; P=0.007) and fatigue (PPR: 0.948; P=0.024) were significantly associated with APA test sensitivity. Conclusions: APA test exhibited a low sensitivity in FM patients and it did not distinguish this group of patients from the controls enrolled in this study. Interestingly, positive APA test prevalence increased with less severe pain or fatigue.

Original languageEnglish
Pages (from-to)74-79
Number of pages6
JournalAutoimmunity
Volume41
Issue number1
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Fibromyalgia
Fatigue
Anti-Idiotypic Antibodies
Polymers
Pain
Antibodies
Psoriatic Arthritis
Visual Analog Scale
ROC Curve
Health Status
Area Under Curve
Rheumatoid Arthritis
Anxiety
Enzyme-Linked Immunosorbent Assay
Regression Analysis
Demography
Depression
Control Groups
Population

Keywords

  • Antinuclear antibodies
  • Antipolymer antibodies
  • Fibromyalgia
  • Fibromyalgia syndrome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Sarzi-Puttini, P., Atzeni, F., Franco, M. D., Lama, N., Batticciotto, A., Iannuccelli, C., ... Valesini, G. (2008). Anti-polymer antibodies are correlated with pain and fatigue severity in patients with fibromyalgia syndrome. Autoimmunity, 41(1), 74-79. https://doi.org/10.1080/08916930701620035

Anti-polymer antibodies are correlated with pain and fatigue severity in patients with fibromyalgia syndrome. / Sarzi-Puttini, Piercarlo; Atzeni, Fabiola; Franco, Manuela Di; Lama, Nicola; Batticciotto, Alberto; Iannuccelli, Cristina; Dell'Acqua, Donata; De Portu, Simona; Riccieri, Valeria; Carrabba, Mario; Buskila, Dan; Doria, Andrea; Valesini, Guido.

In: Autoimmunity, Vol. 41, No. 1, 02.2008, p. 74-79.

Research output: Contribution to journalArticle

Sarzi-Puttini, P, Atzeni, F, Franco, MD, Lama, N, Batticciotto, A, Iannuccelli, C, Dell'Acqua, D, De Portu, S, Riccieri, V, Carrabba, M, Buskila, D, Doria, A & Valesini, G 2008, 'Anti-polymer antibodies are correlated with pain and fatigue severity in patients with fibromyalgia syndrome', Autoimmunity, vol. 41, no. 1, pp. 74-79. https://doi.org/10.1080/08916930701620035
Sarzi-Puttini P, Atzeni F, Franco MD, Lama N, Batticciotto A, Iannuccelli C et al. Anti-polymer antibodies are correlated with pain and fatigue severity in patients with fibromyalgia syndrome. Autoimmunity. 2008 Feb;41(1):74-79. https://doi.org/10.1080/08916930701620035
Sarzi-Puttini, Piercarlo ; Atzeni, Fabiola ; Franco, Manuela Di ; Lama, Nicola ; Batticciotto, Alberto ; Iannuccelli, Cristina ; Dell'Acqua, Donata ; De Portu, Simona ; Riccieri, Valeria ; Carrabba, Mario ; Buskila, Dan ; Doria, Andrea ; Valesini, Guido. / Anti-polymer antibodies are correlated with pain and fatigue severity in patients with fibromyalgia syndrome. In: Autoimmunity. 2008 ; Vol. 41, No. 1. pp. 74-79.
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abstract = "Objective: To investigate the prevalence of antipolymer antibody (APA) in patients with fibromyalgia (FM) and to examine its association with FM severity symptoms. Methods: The study population consisted of 79 FM patients and 75 controls: 32 with psoriatic arthritis and 43 with rheumatoid arthritis APA levels were indirectly assayed using a commercial ELISA kit from Corgenix (Westmister, Colorado, USA). Optical density (OD) values were recorded on duplicates of each of the reference and patient samples. Among clinical variables we investigated pain, measured according to visual analog scales (VAS: 0-100), fatigue, stiffness, anxiety, depression, all measured by VAS (0-100), and health status measured by Fibromyalgia Impact Questionnaire (FIQ). Results: Sixteen of the 79 FM patients (20.3{\%}) and 12/78 controls (15.4{\%}) were positive for APAs (P=0.536). Following ROC analysis, area under curve (AUC) was 0.49 (95{\%} CI: 0.40, 0.58). Focusing on FM patients, we observed a correlation between APA titre and pain (τ: -0.221; P=0.020) and fatigue (τ: -0.205; P=0.032) at univariate analysis. Binomial regression analysis, controlling for clinical and demographic variables, showed that pain (PPR: 0.923; P=0.007) and fatigue (PPR: 0.948; P=0.024) were significantly associated with APA test sensitivity. Conclusions: APA test exhibited a low sensitivity in FM patients and it did not distinguish this group of patients from the controls enrolled in this study. Interestingly, positive APA test prevalence increased with less severe pain or fatigue.",
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AU - Sarzi-Puttini, Piercarlo

AU - Atzeni, Fabiola

AU - Franco, Manuela Di

AU - Lama, Nicola

AU - Batticciotto, Alberto

AU - Iannuccelli, Cristina

AU - Dell'Acqua, Donata

AU - De Portu, Simona

AU - Riccieri, Valeria

AU - Carrabba, Mario

AU - Buskila, Dan

AU - Doria, Andrea

AU - Valesini, Guido

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N2 - Objective: To investigate the prevalence of antipolymer antibody (APA) in patients with fibromyalgia (FM) and to examine its association with FM severity symptoms. Methods: The study population consisted of 79 FM patients and 75 controls: 32 with psoriatic arthritis and 43 with rheumatoid arthritis APA levels were indirectly assayed using a commercial ELISA kit from Corgenix (Westmister, Colorado, USA). Optical density (OD) values were recorded on duplicates of each of the reference and patient samples. Among clinical variables we investigated pain, measured according to visual analog scales (VAS: 0-100), fatigue, stiffness, anxiety, depression, all measured by VAS (0-100), and health status measured by Fibromyalgia Impact Questionnaire (FIQ). Results: Sixteen of the 79 FM patients (20.3%) and 12/78 controls (15.4%) were positive for APAs (P=0.536). Following ROC analysis, area under curve (AUC) was 0.49 (95% CI: 0.40, 0.58). Focusing on FM patients, we observed a correlation between APA titre and pain (τ: -0.221; P=0.020) and fatigue (τ: -0.205; P=0.032) at univariate analysis. Binomial regression analysis, controlling for clinical and demographic variables, showed that pain (PPR: 0.923; P=0.007) and fatigue (PPR: 0.948; P=0.024) were significantly associated with APA test sensitivity. Conclusions: APA test exhibited a low sensitivity in FM patients and it did not distinguish this group of patients from the controls enrolled in this study. Interestingly, positive APA test prevalence increased with less severe pain or fatigue.

AB - Objective: To investigate the prevalence of antipolymer antibody (APA) in patients with fibromyalgia (FM) and to examine its association with FM severity symptoms. Methods: The study population consisted of 79 FM patients and 75 controls: 32 with psoriatic arthritis and 43 with rheumatoid arthritis APA levels were indirectly assayed using a commercial ELISA kit from Corgenix (Westmister, Colorado, USA). Optical density (OD) values were recorded on duplicates of each of the reference and patient samples. Among clinical variables we investigated pain, measured according to visual analog scales (VAS: 0-100), fatigue, stiffness, anxiety, depression, all measured by VAS (0-100), and health status measured by Fibromyalgia Impact Questionnaire (FIQ). Results: Sixteen of the 79 FM patients (20.3%) and 12/78 controls (15.4%) were positive for APAs (P=0.536). Following ROC analysis, area under curve (AUC) was 0.49 (95% CI: 0.40, 0.58). Focusing on FM patients, we observed a correlation between APA titre and pain (τ: -0.221; P=0.020) and fatigue (τ: -0.205; P=0.032) at univariate analysis. Binomial regression analysis, controlling for clinical and demographic variables, showed that pain (PPR: 0.923; P=0.007) and fatigue (PPR: 0.948; P=0.024) were significantly associated with APA test sensitivity. Conclusions: APA test exhibited a low sensitivity in FM patients and it did not distinguish this group of patients from the controls enrolled in this study. Interestingly, positive APA test prevalence increased with less severe pain or fatigue.

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