Anti-Purkinje cell antibody as a biological marker in attention deficit/hyperactivity disorder: A pilot study

Francesca Passarelli; Renato Donfrancesco; Paola Nativio; Esterina Pascale; Michela Di Trani; Anna Maria Patti; Antonella Vulcano; Paolo Gozzo; Maria Pia Villa

doi:10.1016/j.jneuroim.2013.02.018

Anti-Purkinje cell antibody as a biological marker in attention deficit/hyperactivity disorder: A pilot study

Francesca Passarelli, Renato Donfrancesco, Paola Nativio, Esterina Pascale, Michela Di Trani, Anna Maria Patti, Antonella Vulcano, Paolo Gozzo, Maria Pia Villa

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

An autoimmune hypothesis has been suggested for several disorders in childhood. The aim of the study was to clarify the role of the cerebellum in ADHD and to evaluate the possible association between anti-Yo antibodies and ADHD. The presence/absence of antibodies was tested by indirect immunofluorescence assay on 30 combined subtype ADHD children, on 19 children with other psychiatric disorders (Oppositional-defiant and Conduct Disorders, Dyslexia) and 27 healthy controls.Results showed a significant positive response to the anti-Yo antibody immunoreactivity in the Purkinje cells of the cerebellum of ADHD children, compared with the control group and the psychiatric non-ADHD children. This association points to an immune dysregulation and the involvement of the cerebellum in ADHD.

Original language	English
Pages (from-to)	67-70
Number of pages	4
Journal	Journal of Neuroimmunology
Volume	258
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2013.02.018
Publication status	Published - 2013

Keywords

ADHD
Anti-Yo antibodies
Cerebellum
Immunofluorescence
Purkinje cells

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

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10.1016/j.jneuroim.2013.02.018

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Anti-Purkinje cell antibody as a biological marker in attention deficit/hyperactivity disorder : A pilot study. / Passarelli, Francesca; Donfrancesco, Renato; Nativio, Paola; Pascale, Esterina; Trani, Michela Di; Patti, Anna Maria; Vulcano, Antonella; Gozzo, Paolo; Villa, Maria Pia.

In: Journal of Neuroimmunology, Vol. 258, No. 1-2, 2013, p. 67-70.

Research output: Contribution to journal › Article › peer-review

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abstract = "An autoimmune hypothesis has been suggested for several disorders in childhood. The aim of the study was to clarify the role of the cerebellum in ADHD and to evaluate the possible association between anti-Yo antibodies and ADHD. The presence/absence of antibodies was tested by indirect immunofluorescence assay on 30 combined subtype ADHD children, on 19 children with other psychiatric disorders (Oppositional-defiant and Conduct Disorders, Dyslexia) and 27 healthy controls.Results showed a significant positive response to the anti-Yo antibody immunoreactivity in the Purkinje cells of the cerebellum of ADHD children, compared with the control group and the psychiatric non-ADHD children. This association points to an immune dysregulation and the involvement of the cerebellum in ADHD.",

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AU - Passarelli, Francesca

AU - Donfrancesco, Renato

AU - Nativio, Paola

AU - Pascale, Esterina

AU - Trani, Michela Di

AU - Patti, Anna Maria

AU - Vulcano, Antonella

AU - Gozzo, Paolo

AU - Villa, Maria Pia

PY - 2013

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Anti-Purkinje cell antibody as a biological marker in attention deficit/hyperactivity disorder: A pilot study

Abstract

Keywords

ASJC Scopus subject areas

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