Abstract
An autoimmune hypothesis has been suggested for several disorders in childhood. The aim of the study was to clarify the role of the cerebellum in ADHD and to evaluate the possible association between anti-Yo antibodies and ADHD. The presence/absence of antibodies was tested by indirect immunofluorescence assay on 30 combined subtype ADHD children, on 19 children with other psychiatric disorders (Oppositional-defiant and Conduct Disorders, Dyslexia) and 27 healthy controls.Results showed a significant positive response to the anti-Yo antibody immunoreactivity in the Purkinje cells of the cerebellum of ADHD children, compared with the control group and the psychiatric non-ADHD children. This association points to an immune dysregulation and the involvement of the cerebellum in ADHD.
| Original language | English |
|---|---|
| Pages (from-to) | 67-70 |
| Number of pages | 4 |
| Journal | Journal of Neuroimmunology |
| Volume | 258 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2013 |
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Keywords
- ADHD
- Anti-Yo antibodies
- Cerebellum
- Immunofluorescence
- Purkinje cells
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology
Cite this
Anti-Purkinje cell antibody as a biological marker in attention deficit/hyperactivity disorder : A pilot study. / Passarelli, Francesca; Donfrancesco, Renato; Nativio, Paola; Pascale, Esterina; Trani, Michela Di; Patti, Anna Maria; Vulcano, Antonella; Gozzo, Paolo; Villa, Maria Pia.
In: Journal of Neuroimmunology, Vol. 258, No. 1-2, 2013, p. 67-70.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anti-Purkinje cell antibody as a biological marker in attention deficit/hyperactivity disorder
T2 - A pilot study
AU - Passarelli, Francesca
AU - Donfrancesco, Renato
AU - Nativio, Paola
AU - Pascale, Esterina
AU - Trani, Michela Di
AU - Patti, Anna Maria
AU - Vulcano, Antonella
AU - Gozzo, Paolo
AU - Villa, Maria Pia
PY - 2013
Y1 - 2013
N2 - An autoimmune hypothesis has been suggested for several disorders in childhood. The aim of the study was to clarify the role of the cerebellum in ADHD and to evaluate the possible association between anti-Yo antibodies and ADHD. The presence/absence of antibodies was tested by indirect immunofluorescence assay on 30 combined subtype ADHD children, on 19 children with other psychiatric disorders (Oppositional-defiant and Conduct Disorders, Dyslexia) and 27 healthy controls.Results showed a significant positive response to the anti-Yo antibody immunoreactivity in the Purkinje cells of the cerebellum of ADHD children, compared with the control group and the psychiatric non-ADHD children. This association points to an immune dysregulation and the involvement of the cerebellum in ADHD.
AB - An autoimmune hypothesis has been suggested for several disorders in childhood. The aim of the study was to clarify the role of the cerebellum in ADHD and to evaluate the possible association between anti-Yo antibodies and ADHD. The presence/absence of antibodies was tested by indirect immunofluorescence assay on 30 combined subtype ADHD children, on 19 children with other psychiatric disorders (Oppositional-defiant and Conduct Disorders, Dyslexia) and 27 healthy controls.Results showed a significant positive response to the anti-Yo antibody immunoreactivity in the Purkinje cells of the cerebellum of ADHD children, compared with the control group and the psychiatric non-ADHD children. This association points to an immune dysregulation and the involvement of the cerebellum in ADHD.
KW - ADHD
KW - Anti-Yo antibodies
KW - Cerebellum
KW - Immunofluorescence
KW - Purkinje cells
UR - http://www.scopus.com/inward/record.url?scp=84876720088&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876720088&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2013.02.018
DO - 10.1016/j.jneuroim.2013.02.018
M3 - Article
VL - 258
SP - 67
EP - 70
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -