Anti-retroviral therapy with protease inhibitors decreases virulence enzyme expression in vivo by Candida albicans without selection of avirulent fungus strains or decreasing their anti-mycotic susceptibility

Flavia De Bernardis, Evelina Tacconelli, Francesca Mondello, Adriana Cataldo, Silvia Arancia, Roberto Cauda, Antonio Cassone

Research output: Contribution to journalArticle

Abstract

Highly active anti-retroviral therapies (HAART) with human immunodeficiency virus (HIV) protease inhibitors (PIs) or nonnucleoside reverse-transcriptase inhibitors (NNRTI) were compared for their effect on prevalence, aspartyl proteinase (Sap) production and the biotypes and anti-mycotic sequential susceptibility of Candida spp. isolates from the oral cavity in a longitudinal prospective study. HAART-PI, but not HAART-NNRTI strongly inhibited Sap expression in the oral cavity without exerting any consistent effect on the role of Candida spp. isolation or selection of low virulence or anti-mycotic resistant fungus biotype. More importantly, the sequential isolates of Candida albicans from HAART-PI, but not those from suspended HAART-NNRTI, showed an increased Sap production in vitro. While further demonstrating that HIV-PI inhibit Sap expressions, our results do not support the view that the mentioned inhibition could eliminate Candida or its selection of the oral cavity.

Original languageEnglish
Pages (from-to)27-34
Number of pages8
JournalFEMS Immunology and Medical Microbiology
Volume41
Issue number1
DOIs
Publication statusPublished - May 1 2004

Keywords

  • Biotypes
  • Candida
  • HIV
  • Proteinase inhibitors
  • Proteinase secretion

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Infectious Diseases

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