Anti-ribosomal ribonucleoprotein autoantibodies in systemic lupus erythematosus

P. L. Meroni, G. De Bartolo, Wilma Barcellini, P. S. Riboldi, R. Basile, C. Betterle, C. Zanussi

Research output: Contribution to journalArticle

Abstract

Sera from systemic lupus erythematosus (SLE) patients giving a fluorescent ribosomal pattern on tissue and cell preparations also showed precipitating autoantibodies against purified rat liver ribosomes. Ribosomal antigen is also present in rabbit thymus cellular extract (RTE), since the same sera gave precipitin lines against RTE in identity with ribosomes. Immunofluorescent staining was completely inhibited by serum absorption with ribosomes or with RTE. However ribosomal RNA and RNase or trypsin-treated ribosomes failed to react with these autoantibodies as demonstrated in immunoabsorption and immunodiffusion studies. These data suggest that these sera contain autoantibodies directed against some antigenic site composed of a portion of both RNA and ribosomal protein. Ribosomal autoantibodies were detectable at a low frequency in SLE patients characterized by an active disease and renal involvement.

Original languageEnglish
Pages (from-to)45-54
Number of pages10
JournalJournal of Clinical Immunology
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 1984

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Keywords

  • autoantibodies
  • ribosomes
  • rRNP-precipitins
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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