Anti-Ro(SS-A) 52 kDa and 60 kDa specificities in undifferentiated connective tissue disease

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Autoantibodies to Ro(SS-A) may recognize two different polypeptides, of 52 kDa and 60 kDa, respectively. We used an ELISA with purified human recombinant antigens to conduct a detailed analysis of the specificities of anti-Ro(SS-A) antibodies from 170 patients with definite diagnoses (systemic lupus erythematosus [SLE], n = 55; primary Sjogren's syndrome [PSS], n = 39; systemic sclerosis, n = 9; rheumatoid arthritis [RA], n = 10) or undifferentiated connective tissue disease (UCTD, n = 57). Most of the patients with SLE or PSS had both anti-52 kDa and -60 antibodies; isolated anti-60 kDa antibodies were found in 13% of the SLE patients and in none of the PSS patients, whereas high titers of anti-52 kDa were more common in the PSS than in the SLE patients. In the UCTD patients, the anti-Ro(SS-A) profile showed no significant correlations with clinical features but was associated with the clinical outcome. Over the mean follow-up of five years, definite SLE developed in four of the five UCTD patients with isolated anti-60 kDa vs only one of the remaining 52 patients (P <0.0001); progression to PSS was seen in seven of the 34 patients with both anti-52 kDa and anti-60 kDa vs none of the remaining 23 patients (P = 0.03); none of the 12 patients with isolated anti-52 kDa developed a definite connective tissue disease. Conclusion. Our study suggests that analysis of anti-Ro(SS-A) specificity, may provide useful information for predicting the course of UCTD. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalJoint Bone Spine
Volume67
Issue number3
Publication statusPublished - 2000

Fingerprint

Connective Tissue Diseases
Sjogren's Syndrome
Systemic Lupus Erythematosus
Antibodies
Systemic Scleroderma
Autoantibodies
Anti-Idiotypic Antibodies
Rheumatoid Arthritis
Enzyme-Linked Immunosorbent Assay

Keywords

  • Anti-Ro(SS-A) autoantibodies
  • Undifferentiated connective tissue disease

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

@article{50fc56d6523b4eee9ecd3c09cfbeb071,
title = "Anti-Ro(SS-A) 52 kDa and 60 kDa specificities in undifferentiated connective tissue disease",
abstract = "Autoantibodies to Ro(SS-A) may recognize two different polypeptides, of 52 kDa and 60 kDa, respectively. We used an ELISA with purified human recombinant antigens to conduct a detailed analysis of the specificities of anti-Ro(SS-A) antibodies from 170 patients with definite diagnoses (systemic lupus erythematosus [SLE], n = 55; primary Sjogren's syndrome [PSS], n = 39; systemic sclerosis, n = 9; rheumatoid arthritis [RA], n = 10) or undifferentiated connective tissue disease (UCTD, n = 57). Most of the patients with SLE or PSS had both anti-52 kDa and -60 antibodies; isolated anti-60 kDa antibodies were found in 13{\%} of the SLE patients and in none of the PSS patients, whereas high titers of anti-52 kDa were more common in the PSS than in the SLE patients. In the UCTD patients, the anti-Ro(SS-A) profile showed no significant correlations with clinical features but was associated with the clinical outcome. Over the mean follow-up of five years, definite SLE developed in four of the five UCTD patients with isolated anti-60 kDa vs only one of the remaining 52 patients (P <0.0001); progression to PSS was seen in seven of the 34 patients with both anti-52 kDa and anti-60 kDa vs none of the remaining 23 patients (P = 0.03); none of the 12 patients with isolated anti-52 kDa developed a definite connective tissue disease. Conclusion. Our study suggests that analysis of anti-Ro(SS-A) specificity, may provide useful information for predicting the course of UCTD. (C) 2000 Editions scientifiques et medicales Elsevier SAS.",
keywords = "Anti-Ro(SS-A) autoantibodies, Undifferentiated connective tissue disease",
author = "Norma Belfiore and Silvia Rossi and Francesca Bobbio-Pallavicini and Oscar Epis and Roberta Caporali and Carlomaurizio Montecucco",
year = "2000",
language = "English",
volume = "67",
pages = "183--187",
journal = "Revue du Rhumatisme (English Edition)",
issn = "0035-2659",
publisher = "Elsevier Masson",
number = "3",

}

TY - JOUR

T1 - Anti-Ro(SS-A) 52 kDa and 60 kDa specificities in undifferentiated connective tissue disease

AU - Belfiore, Norma

AU - Rossi, Silvia

AU - Bobbio-Pallavicini, Francesca

AU - Epis, Oscar

AU - Caporali, Roberta

AU - Montecucco, Carlomaurizio

PY - 2000

Y1 - 2000

N2 - Autoantibodies to Ro(SS-A) may recognize two different polypeptides, of 52 kDa and 60 kDa, respectively. We used an ELISA with purified human recombinant antigens to conduct a detailed analysis of the specificities of anti-Ro(SS-A) antibodies from 170 patients with definite diagnoses (systemic lupus erythematosus [SLE], n = 55; primary Sjogren's syndrome [PSS], n = 39; systemic sclerosis, n = 9; rheumatoid arthritis [RA], n = 10) or undifferentiated connective tissue disease (UCTD, n = 57). Most of the patients with SLE or PSS had both anti-52 kDa and -60 antibodies; isolated anti-60 kDa antibodies were found in 13% of the SLE patients and in none of the PSS patients, whereas high titers of anti-52 kDa were more common in the PSS than in the SLE patients. In the UCTD patients, the anti-Ro(SS-A) profile showed no significant correlations with clinical features but was associated with the clinical outcome. Over the mean follow-up of five years, definite SLE developed in four of the five UCTD patients with isolated anti-60 kDa vs only one of the remaining 52 patients (P <0.0001); progression to PSS was seen in seven of the 34 patients with both anti-52 kDa and anti-60 kDa vs none of the remaining 23 patients (P = 0.03); none of the 12 patients with isolated anti-52 kDa developed a definite connective tissue disease. Conclusion. Our study suggests that analysis of anti-Ro(SS-A) specificity, may provide useful information for predicting the course of UCTD. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

AB - Autoantibodies to Ro(SS-A) may recognize two different polypeptides, of 52 kDa and 60 kDa, respectively. We used an ELISA with purified human recombinant antigens to conduct a detailed analysis of the specificities of anti-Ro(SS-A) antibodies from 170 patients with definite diagnoses (systemic lupus erythematosus [SLE], n = 55; primary Sjogren's syndrome [PSS], n = 39; systemic sclerosis, n = 9; rheumatoid arthritis [RA], n = 10) or undifferentiated connective tissue disease (UCTD, n = 57). Most of the patients with SLE or PSS had both anti-52 kDa and -60 antibodies; isolated anti-60 kDa antibodies were found in 13% of the SLE patients and in none of the PSS patients, whereas high titers of anti-52 kDa were more common in the PSS than in the SLE patients. In the UCTD patients, the anti-Ro(SS-A) profile showed no significant correlations with clinical features but was associated with the clinical outcome. Over the mean follow-up of five years, definite SLE developed in four of the five UCTD patients with isolated anti-60 kDa vs only one of the remaining 52 patients (P <0.0001); progression to PSS was seen in seven of the 34 patients with both anti-52 kDa and anti-60 kDa vs none of the remaining 23 patients (P = 0.03); none of the 12 patients with isolated anti-52 kDa developed a definite connective tissue disease. Conclusion. Our study suggests that analysis of anti-Ro(SS-A) specificity, may provide useful information for predicting the course of UCTD. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

KW - Anti-Ro(SS-A) autoantibodies

KW - Undifferentiated connective tissue disease

UR - http://www.scopus.com/inward/record.url?scp=0034040895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034040895&partnerID=8YFLogxK

M3 - Article

C2 - 10875315

AN - SCOPUS:0034040895

VL - 67

SP - 183

EP - 187

JO - Revue du Rhumatisme (English Edition)

JF - Revue du Rhumatisme (English Edition)

SN - 0035-2659

IS - 3

ER -