Anti-senescence compounds: A potential nutraceutical approach to healthy aging

Felicia Gurău, Simone Baldoni, Francesco Prattichizzo, Emma Espinosa, Francesco Amenta, Antonio Domenico Procopio, Maria Cristina Albertini, Massimiliano Bonafè, Fabiola Olivieri

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

The desire of eternal youth seems to be as old as mankind. However, the increasing life expectancy experienced by populations in developed countries also involves a significantly increased incidence of the most common age-related diseases (ARDs). Senescent cells (SCs) have been identified as culprits of organismal aging. Their number rises with age and their senescence-associated secretory phenotype fuels the chronic, pro-inflammatory systemic state (inflammaging) that characterizes aging, impairing the regenerative ability of stem cells and increasing the risk of developing ARDs. A variegated class of molecules, including synthetic senolytic compounds and natural compounds contained in food, have been suggested to possess anti-senescence activity. Senolytics are attracting growing interest, and their safety and reliability as anti-senescence drugs are being assessed in human clinical trials. Notably, since SCs spread inflammation at the systemic level through pro-oxidant and pro-inflammatory signals, foods rich in polyphenols, which exert antioxidant and anti-inflammatory actions, have the potential to be harnessed as “anti-senescence foods” in a nutraceutical approach to healthier aging. We discuss the beneficial effects of polyphenol-rich foods in relation to the Mediterranean diet and the dietary habits of long-lived individuals, and examine their ability to modulate bacterial genera in the gut.

Original languageEnglish
Pages (from-to)14-31
Number of pages18
JournalAgeing Research Reviews
Volume46
DOIs
Publication statusPublished - Sep 1 2018

Fingerprint

Dietary Supplements
Aging of materials
Food
Aptitude
Polyphenols
Feeding Behavior
Mediterranean Diet
Nutrition
Life Expectancy
Stem cells
Developed Countries
Action Potentials
Reactive Oxygen Species
Anti-Inflammatory Agents
Stem Cells
Antioxidants
Clinical Trials
Inflammation
Phenotype
Safety

Keywords

  • Aging
  • Anti-senescence diet
  • Cellular senescence
  • Polyphenols
  • Senolytic

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Ageing
  • Molecular Biology
  • Neurology

Cite this

Anti-senescence compounds : A potential nutraceutical approach to healthy aging. / Gurău, Felicia; Baldoni, Simone; Prattichizzo, Francesco; Espinosa, Emma; Amenta, Francesco; Procopio, Antonio Domenico; Albertini, Maria Cristina; Bonafè, Massimiliano; Olivieri, Fabiola.

In: Ageing Research Reviews, Vol. 46, 01.09.2018, p. 14-31.

Research output: Contribution to journalReview article

Gurău, Felicia ; Baldoni, Simone ; Prattichizzo, Francesco ; Espinosa, Emma ; Amenta, Francesco ; Procopio, Antonio Domenico ; Albertini, Maria Cristina ; Bonafè, Massimiliano ; Olivieri, Fabiola. / Anti-senescence compounds : A potential nutraceutical approach to healthy aging. In: Ageing Research Reviews. 2018 ; Vol. 46. pp. 14-31.
@article{beed1023c58e441da80a78796328ed6d,
title = "Anti-senescence compounds: A potential nutraceutical approach to healthy aging",
abstract = "The desire of eternal youth seems to be as old as mankind. However, the increasing life expectancy experienced by populations in developed countries also involves a significantly increased incidence of the most common age-related diseases (ARDs). Senescent cells (SCs) have been identified as culprits of organismal aging. Their number rises with age and their senescence-associated secretory phenotype fuels the chronic, pro-inflammatory systemic state (inflammaging) that characterizes aging, impairing the regenerative ability of stem cells and increasing the risk of developing ARDs. A variegated class of molecules, including synthetic senolytic compounds and natural compounds contained in food, have been suggested to possess anti-senescence activity. Senolytics are attracting growing interest, and their safety and reliability as anti-senescence drugs are being assessed in human clinical trials. Notably, since SCs spread inflammation at the systemic level through pro-oxidant and pro-inflammatory signals, foods rich in polyphenols, which exert antioxidant and anti-inflammatory actions, have the potential to be harnessed as “anti-senescence foods” in a nutraceutical approach to healthier aging. We discuss the beneficial effects of polyphenol-rich foods in relation to the Mediterranean diet and the dietary habits of long-lived individuals, and examine their ability to modulate bacterial genera in the gut.",
keywords = "Aging, Anti-senescence diet, Cellular senescence, Polyphenols, Senolytic",
author = "Felicia Gurău and Simone Baldoni and Francesco Prattichizzo and Emma Espinosa and Francesco Amenta and Procopio, {Antonio Domenico} and Albertini, {Maria Cristina} and Massimiliano Bonaf{\`e} and Fabiola Olivieri",
year = "2018",
month = "9",
day = "1",
doi = "10.1016/j.arr.2018.05.001",
language = "English",
volume = "46",
pages = "14--31",
journal = "Ageing Research Reviews",
issn = "1568-1637",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Anti-senescence compounds

T2 - A potential nutraceutical approach to healthy aging

AU - Gurău, Felicia

AU - Baldoni, Simone

AU - Prattichizzo, Francesco

AU - Espinosa, Emma

AU - Amenta, Francesco

AU - Procopio, Antonio Domenico

AU - Albertini, Maria Cristina

AU - Bonafè, Massimiliano

AU - Olivieri, Fabiola

PY - 2018/9/1

Y1 - 2018/9/1

N2 - The desire of eternal youth seems to be as old as mankind. However, the increasing life expectancy experienced by populations in developed countries also involves a significantly increased incidence of the most common age-related diseases (ARDs). Senescent cells (SCs) have been identified as culprits of organismal aging. Their number rises with age and their senescence-associated secretory phenotype fuels the chronic, pro-inflammatory systemic state (inflammaging) that characterizes aging, impairing the regenerative ability of stem cells and increasing the risk of developing ARDs. A variegated class of molecules, including synthetic senolytic compounds and natural compounds contained in food, have been suggested to possess anti-senescence activity. Senolytics are attracting growing interest, and their safety and reliability as anti-senescence drugs are being assessed in human clinical trials. Notably, since SCs spread inflammation at the systemic level through pro-oxidant and pro-inflammatory signals, foods rich in polyphenols, which exert antioxidant and anti-inflammatory actions, have the potential to be harnessed as “anti-senescence foods” in a nutraceutical approach to healthier aging. We discuss the beneficial effects of polyphenol-rich foods in relation to the Mediterranean diet and the dietary habits of long-lived individuals, and examine their ability to modulate bacterial genera in the gut.

AB - The desire of eternal youth seems to be as old as mankind. However, the increasing life expectancy experienced by populations in developed countries also involves a significantly increased incidence of the most common age-related diseases (ARDs). Senescent cells (SCs) have been identified as culprits of organismal aging. Their number rises with age and their senescence-associated secretory phenotype fuels the chronic, pro-inflammatory systemic state (inflammaging) that characterizes aging, impairing the regenerative ability of stem cells and increasing the risk of developing ARDs. A variegated class of molecules, including synthetic senolytic compounds and natural compounds contained in food, have been suggested to possess anti-senescence activity. Senolytics are attracting growing interest, and their safety and reliability as anti-senescence drugs are being assessed in human clinical trials. Notably, since SCs spread inflammation at the systemic level through pro-oxidant and pro-inflammatory signals, foods rich in polyphenols, which exert antioxidant and anti-inflammatory actions, have the potential to be harnessed as “anti-senescence foods” in a nutraceutical approach to healthier aging. We discuss the beneficial effects of polyphenol-rich foods in relation to the Mediterranean diet and the dietary habits of long-lived individuals, and examine their ability to modulate bacterial genera in the gut.

KW - Aging

KW - Anti-senescence diet

KW - Cellular senescence

KW - Polyphenols

KW - Senolytic

UR - http://www.scopus.com/inward/record.url?scp=85048714345&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048714345&partnerID=8YFLogxK

U2 - 10.1016/j.arr.2018.05.001

DO - 10.1016/j.arr.2018.05.001

M3 - Review article

AN - SCOPUS:85048714345

VL - 46

SP - 14

EP - 31

JO - Ageing Research Reviews

JF - Ageing Research Reviews

SN - 1568-1637

ER -