Anti-SSB/La antibodies in Sjogren's syndrome and related autoimmune diseases. Results of a quantitative immunoassay using a highly purified antigen

C. Montecucco, M. Bestagno, A. Cerino, R. Caporali, R. Carnevale, M. Longhi, M. A. Pedrini, G. C B Astaldi-Ricotti

Research output: Contribution to journalArticle

Abstract

A quantitative immunoassay using a highly purified antigen from HeLa cells has allowed us to detect antibodies to SSB/La in 11/20 patients with primary Sjogren's syndrome (SS), 15/33 with SLE, and 11/35 with progressive systemic sclerosis (PSS). However, positive results were found in only 2/12 patients with idiopathic Raynaud's disease and 2/20 with rheumatoid arthritis, including 4 with secondary SS. Anti-SSB/La were associated with extraglandular manifestations in primary SS, and with a diffuse sclerodermic pattern in PSS. In SS, SLE and PSS, a positive anti-SSB/La test was strongly associated with nodal or spleen enlargement and with an increased level of γ-globulins. A direct association was also found with positive tests for rheumatoid factors, anti-SSA/Ro and anti-Scl 70. An inverse relationship was however found with anti-nRNP ± Sm and anticentromere antibodies. Our data suggest that anti-SSB/La antibodies can be regarded as a marker of B-lymphocyte activation in patients with either primary SS, SLE or PSS.

Original languageEnglish
Pages (from-to)5-11
Number of pages7
JournalClinical and Experimental Rheumatology
Volume7
Issue number1
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

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