Anti-thyroid antibodies in Italian scleroderma patients: Association of anti-thyroid peroxidase (anti-TPO) antibodies with HLA-DR15

M. Molteni, M. Barili, N. Eisera, S. Scrofani, B. Mascagni, C. Zulian, R. Scorza

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the frequency of anti-thyroid antibodies in a group of patients with scleroderma (SSc) and to analyze their genetic association with the HLA class II antigens. Methods: Anti-thyroglobulin (anti-TG) and anti-thyroid peroxidase (anti-TPO) antibodies were measured by hemagglutination techniques. Thyroid function was evaluated by determining the levels of FT3, FT4 and TSH. HLA-DR typing was carried out using a standard complement-dependent microlymphocytotoxicity test. Results: The proportions of patients with anti-TG and anti-TPO antibodies were 12% (10/85) and 19% (16/85) respectively. Two patients with anti-thyroid antibodies had overt hypothyroidism and shared the HLA-DR3 allele. The SSc subjects with anti-TPO antibodies showed a higher frequency of the HLA-DR15 allele than the patients without these antibodies. Conclusion: A considerable number of patients with scleroderma have antibodies to thyroid antigens without exhibiting any alterations of their thyroid function. HLA-DR15 is an immunogenic marker for the formation of antibodies against microsomal thyroid peroxidase.

Original languageEnglish
Pages (from-to)529-534
Number of pages6
JournalClinical and Experimental Rheumatology
Volume15
Issue number5
Publication statusPublished - Sep 1997

Keywords

  • Anti-thyroglobulin antibodies
  • Anti-thyroid peroxidase antibodies
  • HLA
  • Scleroderma

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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