Anti-TNF therapy restores the hypothalamic-pituitary-adrenal axis: Annals of the New York Academy of Sciences

Fabiola Atzeni, Rainer H. Straub, Maurizio Cutolo, Piercarlo Sarzi-Puttini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Tumor necrosis factor (TNF) inhibitors are associated with greater improvements in the symptoms and signs of rheumatoid arthritis (RA) and, more importantly, a lower risk of joint damage. TNF is an important mediator of the alterations in neuroendocrine axes characterizing RA. Long-term therapy with anti-TNF agents sensitizes the pituitary gland and improves adrenal androgen secretion, thus stimulating an alternative form of anti-inflammatory action.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages179-181
Number of pages3
Volume1193
DOIs
Publication statusPublished - Apr 2010

Publication series

NameAnnals of the New York Academy of Sciences
Volume1193
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Cortisol
  • Hormones
  • Rheumatoid arthritis
  • TNF inhibitors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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