Anti-tumoral effects of somatostatin analogs: a lesson from the CLARINET study

M. Albertelli, E. Nazzari, S. Sciallero, F. Grillo, S. Morbelli, F. De Cian, G. Cittadini, E. Ambrosetti, A. Ciarmiello, D. Ferone, On behalf of the IRCCS Policlinico San Martino, University of Genova Neuroendocrine Tumor Board

Research output: Contribution to journalArticlepeer-review


Octreotide and lanreotide, the first-generation somatostatin analogs, successfully control hormone hyperproduction, and related syndromes, in patients with acromegaly and neuroendocrine tumors. However, their anti-tumor effect, rather evident in large number of pituitary adenomas in acromegalic patients, has been hypothesized for a long time in patients with neuroendocrine tumors as well, although a significant tumor shrinkage has rarely been observed. However, the recent publication of the CLARINET study has strengthened the evidence, already emerged with the PROMID trial, that the long-term treatment with the first-generation long-acting somatostatin analogs may exert an anti-tumor activity on G1 and G2 enteropancreatic neuroendocrine tumors, as well. After the publication, majority of international guidelines have updated their algorithms in line with these results and this class of drugs obtained the indication as anti-tumor agents in the majority of patients with neuroendocrine tumors.

Original languageEnglish
Pages (from-to)1265-1269
Number of pages5
JournalJournal of Endocrinological Investigation
Issue number11
Publication statusPublished - Nov 1 2017


  • Anti-tumor effect
  • Clinical trial
  • Lanreotide
  • Neuroendocrine tumors
  • Octreotide
  • Somatostatin analogs

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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