Antiadrenergic effects of propafenone: Clinical evidence

F. Lombardi, L. Dalla Vecchia, D. Torzillo, M. L. Finocchiaro, G. Sandrone, E. Cappiello

Research output: Contribution to journalArticlepeer-review


To evaluate whether the antiarrhythmic action of Propafenone is associated to alterations of neural mechanisms regulating cardiovascular function we analyzed RR variability in 10 patients in whom the drug suppressed high degree ventricular arrhythmias. After drug administration, in absence of changes of RR interval, there was a significant reduction of RR variance and of LF component of RR variability. On the contrary HF markedly increased. The observed changes in spectral indices of, respectively, sympathetic and parasympathetic modulation of heart period, suggest that Propafenone administration determines a shift of sympatho-vagal balance toward a condition of diminished sympathetic and enhanced vagal tone.

Original languageEnglish
Pages (from-to)403-408
Number of pages6
JournalNew Trends in Arrhythmias
Issue number4
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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