Antiangiogenesis by chemotherapeutic agents

Domenico Ribatti, Angelo Vacca, Francesca Merchionne, Marco Presta

Research output: Contribution to journalArticlepeer-review

Abstract

Many tumors are not curable because current treatments primarily target the tumor cells. Intratumoral endothelial cells, on the other hand, proliferate rapidly and are sensitive to the cytotoxic effects of chemotherapeutic agents. This review summarizes the literature concerning the antiangiogenic effects of these agents when administered alone or in combination with other angiogenesis inhibitors.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalMini-Reviews in Medicinal Chemistry
Volume5
Issue number3
Publication statusPublished - Mar 2005

Keywords

  • Angiogenesis
  • Antiangiogenesis
  • Chemotherapeutic agents
  • Endothelial cells
  • Tumor progression

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemistry(all)
  • Pharmacology

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