TY - JOUR
T1 - Antiangiogenic metronomic chemotherapy and hyperthermia in the palliation of advanced cancer
T2 - Original article
AU - Franchi, F.
AU - Grassi, P.
AU - Ferro, D.
AU - Pigliucci, G.
AU - De Chicchis, M.
AU - Castigliani, G.
AU - Pastore, C.
AU - Seminara, P.
PY - 2007/5
Y1 - 2007/5
N2 - Among a large series of cancer patients treated with a combination of chemotherapy and sessions of hyperthermia, particular attention was given to a specific group of patients with advanced cancer who refused standard, aggressive, treatment. In these cases, hyperthermia was associated to low-dose (metronomic) chemotherapy. No toxicity was reported in any of our patients, while a marginal benefit in terms of tumour progression was observed. During therapy, we could detect a coagulative perturbation that deserves careful discussion. In our opinion, this experience should be matter of debate to conclude if current response criteria (WHO/UICC and RECIST) in treating cancer patients are really suitable tools to evaluate new, and non-aggressive anticancer strategies.
AB - Among a large series of cancer patients treated with a combination of chemotherapy and sessions of hyperthermia, particular attention was given to a specific group of patients with advanced cancer who refused standard, aggressive, treatment. In these cases, hyperthermia was associated to low-dose (metronomic) chemotherapy. No toxicity was reported in any of our patients, while a marginal benefit in terms of tumour progression was observed. During therapy, we could detect a coagulative perturbation that deserves careful discussion. In our opinion, this experience should be matter of debate to conclude if current response criteria (WHO/UICC and RECIST) in treating cancer patients are really suitable tools to evaluate new, and non-aggressive anticancer strategies.
KW - Chemotherapy
KW - Hyperthermia
KW - Palliative care
KW - Tumour
UR - http://www.scopus.com/inward/record.url?scp=34248562373&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34248562373&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2354.2006.00737.x
DO - 10.1111/j.1365-2354.2006.00737.x
M3 - Article
C2 - 17508946
AN - SCOPUS:34248562373
VL - 16
SP - 258
EP - 262
JO - European Journal of Cancer Care
JF - European Journal of Cancer Care
SN - 0961-5423
IS - 3
ER -