Antiangiogenic naphthalene sulfonic distamycin-A derivatives tightly interact with human basic fibroblast growth factor

Moreno Zamai, Abraham H. Parola, Maria Grandi, Nicola Mongelli, Valeria R. Caiolfa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A novel class of non-cytotoxic synthetic sulfonated distamycin A derivatives (suradistas) was shown to have anti-angiogenic activity in vitro and in vivo. The in vivo antitumor activity is probably due to the growth factor binding properties of these molecules. Three of them were spectroscopically characterized. For the first time, their direct interaction with human recombinant basic fibroblast growth factor was proved by means of steady-state fluorescence anisotropy and equilibrium affinity chromatography. Suradista:bFGF complexes had dissociation constants in the range of 10 -6-10 -7 M.

Original languageEnglish
Pages (from-to)36-44
Number of pages9
JournalMedicinal Chemistry Research
Volume7
Issue number1
Publication statusPublished - 1997

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Affinity chromatography
Fluorescence Polarization
Fibroblast Growth Factor 2
Affinity Chromatography
Intercellular Signaling Peptides and Proteins
Anisotropy
Fluorescence
Derivatives
Molecules
recombinant KCB-1 protein
stallimycin
naphthalene
In Vitro Techniques

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry

Cite this

Antiangiogenic naphthalene sulfonic distamycin-A derivatives tightly interact with human basic fibroblast growth factor. / Zamai, Moreno; Parola, Abraham H.; Grandi, Maria; Mongelli, Nicola; Caiolfa, Valeria R.

In: Medicinal Chemistry Research, Vol. 7, No. 1, 1997, p. 36-44.

Research output: Contribution to journalArticle

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