Antiangiogenic strategies in neuroblastoma

Domenico Ribatti, Mirco Ponzoni

Research output: Contribution to journalArticle

Abstract

Promising new antiangiogenic strategies are emerging for the treatment of cancer and the inhibition of angiogenesis could represent a powerful adjunct to traditional therapy of malignant tumors. Over the last ten years several reports have been published concerning the relationship between tumor progression and angiogenesis in neuroblastoma in experimental models in vitro and in vivo. Moreover, a high vascular index in neuroblastoma correlates with poor prognosis, suggesting dependence of aggressive tumor growth on active angiogenesis. Here, we present an overview of recent advances in antiangiogenesis in neuroblastoma and describe the most important active substances, preclinical and clinical data, as well as future pespectives.

Original languageEnglish
Pages (from-to)27-34
Number of pages8
JournalCancer Treatment Reviews
Volume31
Issue number1
DOIs
Publication statusPublished - Feb 2005

Keywords

  • Antiangiogenesis
  • Neuroblastoma
  • Tumor progression

ASJC Scopus subject areas

  • Oncology
  • Urology

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