Antiatherogenic effect of grape flavonoids in an ex vivo model

N. A. Nikitina; I. A. Sobenin; V. A. Myasoedova; V. V. Korennaya; A. A. Mel&apos;nichenko; E. M. Khalilov; A. N. Orekhov

doi:10.1007/s10517-006-0260-7

Antiatherogenic effect of grape flavonoids in an ex vivo model

N. A. Nikitina, I. A. Sobenin, V. A. Myasoedova, V. V. Korennaya, A. A. Mel'nichenko, E. M. Khalilov, A. N. Orekhov

Centro Cardiologico Monzino

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of grape phytoestrogens on cholesterol accumulation were studied in primary culture of human blood monocytes incubated with blood serum from postmenopausal women obtained before and 2, 4, and 6 h after single intake of plant components of grapes. Phytoestrogens from grape seeds, pressed out grapes, and fermented grape ridges prevent cholesterol accumulation in cells and can be regarded as prospective components for the development of natural preparations for the prevention of atherosclerosis in postmenopausal women.

Original language	English
Pages (from-to)	712-715
Number of pages	4
Journal	Bulletin of Experimental Biology and Medicine
Volume	141
Issue number	6
DOIs	https://doi.org/10.1007/s10517-006-0260-7
Publication status	Published - Jun 2006

Keywords

Atherosclerosis
Human monocyte culture
Intracellular accumulation of cholesterol
Phytoestrogens
Postclimacteric period

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Antiatherogenic effect of grape flavonoids in an ex vivo model",

abstract = "The effects of grape phytoestrogens on cholesterol accumulation were studied in primary culture of human blood monocytes incubated with blood serum from postmenopausal women obtained before and 2, 4, and 6 h after single intake of plant components of grapes. Phytoestrogens from grape seeds, pressed out grapes, and fermented grape ridges prevent cholesterol accumulation in cells and can be regarded as prospective components for the development of natural preparations for the prevention of atherosclerosis in postmenopausal women.",

keywords = "Atherosclerosis, Human monocyte culture, Intracellular accumulation of cholesterol, Phytoestrogens, Postclimacteric period",

author = "Nikitina, {N. A.} and Sobenin, {I. A.} and Myasoedova, {V. A.} and Korennaya, {V. V.} and Mel'nichenko, {A. A.} and Khalilov, {E. M.} and Orekhov, {A. N.}",

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AU - Nikitina, N. A.

AU - Sobenin, I. A.

AU - Myasoedova, V. A.

AU - Korennaya, V. V.

AU - Mel'nichenko, A. A.

AU - Khalilov, E. M.

AU - Orekhov, A. N.

PY - 2006/6

Y1 - 2006/6

N2 - The effects of grape phytoestrogens on cholesterol accumulation were studied in primary culture of human blood monocytes incubated with blood serum from postmenopausal women obtained before and 2, 4, and 6 h after single intake of plant components of grapes. Phytoestrogens from grape seeds, pressed out grapes, and fermented grape ridges prevent cholesterol accumulation in cells and can be regarded as prospective components for the development of natural preparations for the prevention of atherosclerosis in postmenopausal women.

AB - The effects of grape phytoestrogens on cholesterol accumulation were studied in primary culture of human blood monocytes incubated with blood serum from postmenopausal women obtained before and 2, 4, and 6 h after single intake of plant components of grapes. Phytoestrogens from grape seeds, pressed out grapes, and fermented grape ridges prevent cholesterol accumulation in cells and can be regarded as prospective components for the development of natural preparations for the prevention of atherosclerosis in postmenopausal women.

KW - Atherosclerosis

KW - Human monocyte culture

KW - Intracellular accumulation of cholesterol

KW - Phytoestrogens

KW - Postclimacteric period

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Antiatherogenic effect of grape flavonoids in an ex vivo model

Abstract

Keywords

ASJC Scopus subject areas

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