Antibacterial activities of ferrocenoyl- and cobaltocenium-peptide bioconjugates

Janine T. Chantson, Maria Vittoria Verga Falzacappa, Sergio Crovella, Nils Metzler-Nolte

Research output: Contribution to journalArticlepeer-review

Abstract

The peptide and metallocene-peptide bioconjugates R-Arg-Arg-Phe-NH 2, R-Phe-Arg-Phe-NH 2 where R = H, Fe(Cp)(C 5H 4-CO), Co(Cp)(C 5H 4-CO) + and R′-Gly-Trp-Arg-Arg-Phe-NH 2, R′-Trp-Arg-Arg-Phe- NH 2, where R′ = n-C 5H 11CO, Fe(Cp)(C 5H 4-CO), Co(Cp)(C 5H 4-CO) +, and Arg = l-arginine, Gly = l-glycine, Phe = l-phenylalanine, Trp = l-tryptophan were prepared by solid phase peptide synthesis (SPPS). The compounds were purified by RP-HPLC and characterized by ESI-MS and NMR spectroscopy. Antibacterial properties of the compounds were determined by minimum inhibitory concentration (MIC) tests against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus.

Original languageEnglish
Pages (from-to)4564-4572
Number of pages9
JournalJournal of Organometallic Chemistry
Volume690
Issue number21-22
DOIs
Publication statusPublished - Nov 1 2005

Keywords

  • Antibacterial agents
  • Bioorganometallic chemistry
  • Cobaltocenium
  • Ferrocene
  • Peptides
  • Solid phase synthesis

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Materials Science (miscellaneous)
  • Materials Chemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Biochemistry

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